Irisin: a new molecular marker and target in metabolic disorder

Lipids in Health and Disease

Shen Qu³  Aaron M Gusdon²  Yue-ye Huang¹  Jia-qi Chen³ 

[1] Department of Endocrinology and Metabolism, Shanghai 10th People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, China;Department of Neurology, Weill Cornell Medical College, New York, NY 10065, USA;Nanjing Medical University, Nanjing, Jiangsu 210029, China

关键词: Metabolic diseases;    Obesity;    Irisin;   

Others  :  1135947
DOI  :  10.1186/1476-511X-14-2

 received in 2014-10-18, accepted in 2015-01-07,  发布年份 2015

【 摘 要 】

Irisin is a newly discovered exercise-mediated myokine which regulates energy metabolism and has been the subject of much recent research. Irisin plays an important role in metabolic diseases making it a potential new target to combat obesity and its associated disorders, such as T2DM. However, the results of several recent studies investigating the effects of irisin have been controversial. The present review will introduce the discovery of irisin, the role of irisin in metabolic disorders, possible mechanisms, and unanswered questions for future research.

【 授权许可】

   
2015 Chen et al.; licensee BioMed Central.

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