Overexpression of MACC1 and Its significance in human Breast Cancer Progression

Cell & Bioscience

Mengfeng Li¹  Xun Zhu¹  Caisheng Ye²  Jueheng Wu¹  Lishan Fang¹  Junchao Cai¹  Huizhong Zhang³  Yongbo Huang¹ 

[1] Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou, Guangdong 510080, China;Department of Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China;Department of Pathology, Sun Yat-sen University Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong, China

关键词: Metastasis;    MACC1;    Cancer progression;    Breast cancer;    Biomarker;   

Others  :  792912
DOI  :  10.1186/2045-3701-3-16

 received in 2012-12-16, accepted in 2013-02-04,  发布年份 2013

【 摘 要 】

Background

Metastasis-associated in colon cancer-1 (MACC1) was first identified as a transcriptional activator for proto-oncogene c-MET expression, and its overexpression is frequently associated with metastatic progression for multiply tumor types. In the present study, we analyzed for the first time the expression of MACC1 in breast cancer and its correlation with clinicopathologic features, including metastasis and patient survival.

Results

MACC1 protein expression was analyzed in two cohorts of clinicopathologically characterized breast cancer using immunohistochemistry. Statistical analysis showed a significant correlation of MACC1 expression with the primary tumor, lymph node metastasis, distant metastasis classifications as well as the clinical staging in breast cancer patients. Moreover, overexpression of MACC1 was associated with both a reduced recurrence-free survival (RFS) and poorer patients' overall survival (OS). Multivariate analysis with a Cox proportional-hazards model suggested that MACC1 expression was an independent prognostic indicator for RFS and OS. Stratification of breast cancer patients according to the estrogen receptor (ER) status revealed that MACC1 was prognostic for both ER-negative and ER-positive patients.

Conclusions

MACC1 may represent a potentially useful biomarker for the prognosis of breast cancer patients and might be involved in progression of breast cancer.

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

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