Cardio-ankle vascular index is associated with cardiovascular target organ damage and vascular structure and function in patients with diabetes or metabolic syndrome, LOD-DIABETES study: a case series report

Cardiovascular Diabetology

Luís García-Ortiz¹  Jose Angel Maderuelo-Fernandez³  Emiliano Rodríguez-Sanchez¹  Marta Gomez-Sanchez³  Leticia Gómez-Sánchez³  Cristina Agudo-Conde³  María Carmen Patino-Alonso²  José Ignacio Recio-Rodríguez³  Manuel Ángel Gómez-Marcos¹ 

[1] Medicine Department, University of Salamanca, Salamanca, Spain;Statistics Department, University of Salamanca, Salamanca, Spain;Primary Care Research Unit, the Alamedilla Health Center, Avda. Comuneros 27, Salamanca, 37003, Spain

关键词: Metabolic syndrome;    Diabetes mellitus type 2;    Cardiovascular risk;    Vascular function;    Vascular structure;    Cardio ankle vascular index;    Target organ damage;   

Others  :  1118919
DOI  :  10.1186/s12933-014-0167-y

 received in 2014-10-25, accepted in 2014-12-28,  发布年份 2015

【 摘 要 】

Background

The cardio ankle vascular index (CAVI) is a new index of the overall stiffness of the artery from the origin of the aorta to the ankle. This index can estimate the risk of atherosclerosis. We aimed to find the relationship between CAVI and target organ damage (TOD), vascular structure and function, and cardiovascular risk factors in Caucasian patients with type 2 diabetes mellitus or metabolic syndrome.

Methods

We included 110 subjects from the LOD-Diabetes study, whose mean age was 61 ± 11 years, and 37.3% were women. Measurements of CAVI, brachial ankle pulse wave velocity (ba-PWV), and ankle brachial index (ABI) were taken using the VaSera device. Cardiovascular risk factors, renal function by creatinine, glomerular filtration rate, and albumin creatinine index were also obtained, as well as cardiac TOD with ECG and vascular TOD and carotid intima media thickness (IMT), carotid femoral PWV (cf-PWV), and the central and peripheral augmentation index (CAIx and PAIx). The Framingham-D’Agostino scale was used to measure cardiovascular risk.

Results

Mean CAVI was 8.7 ± 1.3. More than half (54%) of the participants showed one or more TOD (10% cardiac, 13% renal; 48% vascular), and 13% had ba-PWV ≥ 17.5 m/s. Patients with any TOD had the highest CAVI values: 1.15 (CI 95% 0.70 to 1.61, p < 0.001) and 1.14 (CI 95% 0.68 to 1.60, p < 0.001) when vascular TOD was presented, and 1.30 (CI 95% 0.51 to 2.10, p = 0.002) for the cardiac TOD. The CAVI values had a positive correlation with HbA1c and systolic and diastolic blood pressure, and a negative correlation with waist circumference and body mass index. The positive correlations of CAVI with IMT (β = 0.29; p < 0.01), cf-PWV (β = 0.83; p < 0.01), ba-PWV (β = 2.12; p < 0.01), CAIx (β = 3.42; p < 0.01), and PAIx (β = 5.05; p = 0.04) remained after adjustment for cardiovascular risk, body mass index, and antihypertensive, lipid-lowering, and antidiabetic drugs.

Conclusions

The results of this study suggest that the CAVI is positively associated with IMT, cf-PWV, ba-PWV, CAIx, and PAIx, regardless of cardiovascular risk and the drug treatment used. Patients with cardiovascular TOD have higher values of CAVI.

Trial registration

Clinical Trials.gov Identifier: NCT01065155 webcite

【 授权许可】

   
2015 Gomez-Marcos et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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