Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma—a multicenter experience

Journal of Therapeutic Ultrasound

Edouard Poncelet¹  Nicolas Laurent¹  Loïc Boulanger⁴  Marc Abehsera²  Jean-Noël Guglielmina⁵  Roussanka Kovatcheva³ 

[1] Department of Imaging, Regional Hospital of Valenciennes, Ave Désandrouin - BP 479, Valenciennes, 59322, France;Department of Medical Imaging, American Hospital of Paris, 63 Bld Victor Hugo, Neuilly-sur-Seine, 92200, France;Department of Thyroid and Metabolic Bone Disorders, University Hospital of Endocrinology, Medical University of Sofia, 2 Zdrave Street, Sofia, 1431, Bulgaria;Department of Gynecological and Breast Surgery, University Hospital of Lille, Ave Eugène Avinée, Lille, 59037, France;Department of Gynecological Surgery, American Hospital of Paris, 63 Bld Victor Hugo, Neuilly-sur-Seine, 92200, France

关键词: Minimally invasive treatment;    Ultrasound (US)-guided high-intensity focused ultrasound (HIFU);    Breast fibroadenoma;   

Others  :  1132936
DOI  :  10.1186/s40349-014-0022-3

【 摘 要 】

Background

The aim of our multicenter study was to assess the clinical outcome and safety of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in patients with breast fibroadenoma (FA).

Methods

From May 2011 to February 2013, 42 women with 51 FA in one or both breasts were selected for treatment with US-guided HIFU. Eight of 51 FA were treated twice. Patients’ age ranged from 16 to 52 years (mean 32 years). All patients with FA underwent core needle biopsy with histological confirmation. HIFU treatment was performed as an outpatient procedure under conscious sedation. Exclusion criteria were pregnant or lactating women, microcalcifications within the lesion at mammogram, history of breast cancer, previous laser or radiation therapy, and breast implant in the same breast. All patients signed written informed consent. After the treatment, follow-up US with volume evaluation was performed at 2, 6, and 12 months.

Results

The FA mean baseline volume was 3.89 ml (0.34–19.66 ml). At 2-month follow-up, the mean volume reduction was 33.2% ± 19.1% and achieved significance at 6-month (59.2% ± 18.2%, p < 0.001) and 12-month (72.5% ± 16.7%, p < 0.001) follow-up. Related side effects as superficial skin burn with blister-like aspect in three patients and hyperpigmentation over the treated area in one patient were transient and resolved spontaneously. In one patient, asymptomatic subcutaneous induration persisted at the end of the study.

Conclusions

US-guided HIFU treatment is an effective noninvasive method for the treatment of breast FA and well tolerated by the patients. Preliminary results are encouraging and show that HIFU could be an alternative to surgery for breast FA.

【 授权许可】

   
2015 Kovatcheva et al.; licensee BioMed Central.

【 图 表 】

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