Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis

Journal of Negative Results in Biomedicine

Joni A Cirelli¹  Silvana RP Orrico¹  Yeon J Kim¹  Aline C Viana¹  Giovana Anovazzi¹  Patrícia M Sogumo²  Rivelto Renzi²  Karen MC Curtis²  Raquel M Scarel-Caminaga² 

[1] UNESP - São Paulo State University, School of Dentistry at Araraquara, Department of Oral Diagnosis and Surgery, SP, Brazil;UNESP - São Paulo State University, School of Dentistry at Araraquara, Department of Morphology, SP, Brazil

关键词: periodontal disease;    genetic polymorphism;    cytokine;    chemokine;    CXCR1;   

Others  :  820592
DOI  :  10.1186/1477-5751-10-14

 received in 2011-05-26, accepted in 2011-11-03,  发布年份 2011

【 摘 要 】

Background

The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis.

Findings

Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05).

Conclusions

The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population.

【 授权许可】

   
2011 Scarel-Caminaga et al; licensee BioMed Central Ltd.

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