Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

Diabetology & Metabolic Syndrome

Li Zhou⁵  Qing-Sheng Mi⁵  Jin-Xiong She¹  Abert M Levin⁴  Yangxin Deng⁶  Hongzhi He³  Xiaofan Mi² 

[1] Center for Biotechnology and Genomic Medicine, Georgia Health Sciences University, 1120 15th street, Augusta, GA 30912, USA;MedStart Program, Irvin D. Reid Honors College, Wayne State University, 5155 Gullen Mall, Detroit, MI 48202, USA;Department of Dermatology, Henry Ford Health System, 1 Ford Place, Detroit, MI 48202, USA;Department of Public Health Sciences, Henry Ford Health System, 1 Ford Place, Detroit, MI 48202, USA;Division of Endocrinology, Diabetes, Bone and Mineral Disorders/Department of Internal Medicine, Henry Ford Health System, 1 Ford Place, Detroit, MI 48202, USA;Department of Endocrinology, Affiliated Hospital, Taishan Medical College, 706 Taishan Blvd, Taian, Shandong Province, 27100, P. R. China

关键词: microRNAs;    polymorphism;    Type 1 diabetes;   

Others  :  817541
DOI  :  10.1186/1758-5996-3-27

 received in 2011-08-05, accepted in 2011-10-20,  发布年份 2011

【 摘 要 】

MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes.

【 授权许可】

   
2011 Mi et al; licensee BioMed Central Ltd.

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