Biochemical view on: Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes

Diabetology & Metabolic Syndrome

Metin Uyanik¹  Erdim Sertoglu³  Huseyin Kayadibi² 

[1] Corlu Military Hospital, Biochemistry Laboratory, Tekirdag, Turkey;Adana Military Hospital, Medical Biochemistry Laboratory, Adana 01150, Turkey;Ankara Mevki Military Hospital, Anittepe Dispensary, Biochemistry Laboratory, Ankara, Turkey

关键词: Homocysteine;    Endothelial dysfunction;    Microangiopathy;    Cardiovascular risk;    Gestational diabetes;   

Others  :  1143881
DOI  :  10.1186/s13098-015-0023-6

 received in 2014-09-30, accepted in 2015-03-11,  发布年份 2015

【 摘 要 】

Women diagnosed with gestational diabetes mellitus have an increased risk of developing diabetes mellitus, which is a known risk factor for cardiovascular disease and insulin resistance. In the recently published article by Zajdenverg et al., they aimed to identify endothelial dysfunction and cardiovascular risk factors in women with previous gestational diabetes mellitus. However, authors did not evaluate the role of total homocysteine, which has important effects for endothelial dysfunction. Vitamin B12 and folic acid are important vitamins since their deficiency may lead to the probable microvascular abnormalities by increasing the tHcy, which is an independent risk factor for endothelial dysfunction.

【 授权许可】

   
2015 Kayadibi et al.; licensee BioMed Central.

【 参考文献 】

• [1]Zajdenverg L, Rodacki M, Faria JP, Pires ML, Oliveira JE, Halfoun VL: Precocious markers of cardiovascular risk and vascular damage in apparently healthy women with previous gestational diabetes. Diabetol Metab Syndr. 2014, 6:63. BioMed Central Full Text
• [2]Idzior-Waluś B, Cyganek K, Sztefko K, Seghieri G, Breschi MC, Waluś-Miarka M, et al.: Total plasma homocysteine correlates in women with gestational diabetes. Arch Gynecol Obstet 2008, 278(4):309-13.
• [3]Katre P, Bhat D, Lubree H, Otiv S, Joshi S, Joglekar C, et al.: Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status. Asia Pac J Clin Nutr 2010, 19(3):335-43.