Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?

Journal of Neuroinflammation

Luigi Bubacco¹  Marco Bisaglia¹  Laura Civiero¹  Elisa Greggio¹ 

[1] Department of Biology, University of Padova, Via Ugo Bassi 58/B, Padova, 35121, ITALY

关键词: Cytokines;    Neuroinflammation;    Leucine-rich repeat kinase 2 (LRRK2);    Parkinson’s disease;   

Others  :  1212614
DOI  :  10.1186/1742-2094-9-94

 received in 2012-02-28, accepted in 2012-05-17,  发布年份 2012

【 摘 要 】

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson’s disease; Crohn’s disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon γ, and its function as negative regulator of the immune response transcription factor NFAT1. In this review we discuss the most recent findings regarding how LRRK2 could be a player in the inflammatory response and we propose a scenario where the detrimental effects mediated by Parkinson’s disease LRRK2 mutations may initiate in the periphery and extend to the central nervous system as a consequence of increased levels of pro-inflammatory factors permeable to the blood brain barrier.

【 授权许可】

   
2012 Greggio et al.; licensee BioMed Central Ltd.

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