High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice

Longevity & Healthspan

Luis Valmor Portela¹  Diogo Onofre Souza¹  Adriano Martimbianco de Assis¹  Marcelo de Oliveira Dietrich²  Alexandre Pastoris Muller¹ 

[1] Programa de Pós-graduaçãoemBioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 – Anexo I, Porto Alegre, RS, 90035-000, Brazil;Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA

关键词: Survival;    Memory;    High-fat diet;    Glucose tolerance;    Obesity;   

Others  :  803794
DOI  :  10.1186/2046-2395-2-10

 received in 2012-12-20, accepted in 2013-04-05,  发布年份 2013

【 摘 要 】

Background

Obesity is a health problem that is reaching epidemic proportions worldwide. We investigated the effects of a life-long high saturated fat and low carbohydrate (HF) diet on the body mass, glucose tolerance, cognitive performance and lifespan of mice.

Findings

C57BL/6J mice were fed with a HF diet (60% kcal/fat) or control diets (15% kcal/fat) for 27 months. One-half of the mice on the HF diet developed obesity (diet-induced obese (DIO) mice), whereas the remaining mice were diet resistant (DR). At 8 months of age, both DIO and DR groups had increased hyperglycemic response during a glucose tolerance test, which was normalized in 16-month-old mice. At this latter time point, all groups presented similar performance in cognitive tests (Morris water maze and inhibitory avoidance). The survival curves of the HF and control diet groups started to diverge at 15 months of age and, after 27 months, the survival rate of mice in the DIO and DR groups was 40%, whereas in the control diet group it was 75%.

Conclusions

AHFdiet decreased the survival of mice independent of bodyweight.

【 授权许可】

   
2013 Muller et al.; licensee BioMed Central Ltd.

【 图 表 】

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