Response of follicular dendritic cell sarcoma to gemcitabine and docetaxel: report of two cases and literature review

Clinical Sarcoma Research

Robert M Conry¹ 

[1] Division of Hematology & Oncology, University of Alabama at Birmingham, 2145 Bonner Way, Birmingham, AL 35243, USA

关键词: Metastatic;    Chemotherapy;    Docetaxel;    Gemcitabine;    Sarcoma;    Follicular dendritic cell;   

Others  :  861255
DOI  :  10.1186/2045-3329-4-6

 received in 2014-04-16, accepted in 2014-06-25,  发布年份 2014

【 摘 要 】

Follicular dendritic cell sarcoma is a rare malignancy arising from follicular dendritic cells, which form a meshwork within lymphoid follicles. Traditional treatment of metastatic disease with CHOP chemotherapy, the most commonly used regimen for lymphoid malignancies, has met with limited success. I report herein two cases of follicular dendritic cell sarcoma metastatic to the liver treated with the combination of gemcitabine and docetaxel showing unprecedented response in this disease. These observations coupled with recent evidence of a mesenchymal origin of follicular dendritic cells support the premise that this malignancy should be treated similar to other adult soft tissue sarcomas.

【 授权许可】

   
2014 Conry; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Aguzzi A, Krautler NJ: Characterizing follicular dendritic cells: a progress report. Eur J Immunol 2010, 40:2134-2138.
• [2]Chan AC, Chan KW, Chan JK, Au WY, Ho WK, Ng WM: Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman’s disease of the nasopharynx: tracing its evolution by sequential biopsies. Histopathology 2001, 38:510-518.
• [3]Hwang SO, Lee TH, Bae SH, Cho HD, Choi KH, Park SH, Kim CH, Kim SJ: Transformation of Castleman’s disease into follicular dendritic cell sarcoma, presenting as an asymptomatic intra-abdominal mass. Korean J Gastroenterol 2013, 62:131-134.
• [4]Pan ST, Cheng CY, Lee NS, Liang PI, Chuang SS: Follicular dendritic cell sarcoma of the inflammatory pseudotumor-like variant presenting as a colonic polyp. Korean J Pathol 2014, 48:140-145.
• [5]Shinagare AB, Ramaiya NH, Jagannathan JP, Hornick JL, Swanson RS: Primary follicular dendritic cell sarcoma of liver treated with cyclophosphamide, doxorubicin, vincristine, and prednisone regimen and surgery. J Clin Oncol 2011, 29:e849-e851.
• [6]Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, Brink R, Heikenwalder M, Aguzzi A: Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell 2012, 150:194-206.
• [7]Khalid T, Folman R: Symptoms in cancer patients and an unusual tumor: Case 3. Follicular dendritic cell sarcoma. J Clin Oncol 2005, 23:9425-9426.
• [8]Bay JO, Ray-Coquard I, Fayette J, Leyvraz S, Cherix S, Piperno-Neumann S, Chevreau C, Isambert N, Brain E, Emile G, Le Cesne A, Cioffi A, Kwiatkowski F, Coindre JM, Bui NB, Peyrade F, Penel N, Blay JY, Groupe Sarcome Français: Docetaxel and gemcitabine combination in 133 advanced soft-tissue sarcomas: a retrospective analysis. Int J Cancer 2006, 119:706-711.
• [9]Patel SR, Gandhi V, Jenkins J, Papadopolous N, Burgess MA, Plager C, Plunkett W, Benjamin RS: Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine triphosphate accumulation. J Clin Oncol 2001, 19:3483-3489.
• [10]Maki RG, Wathen JK, Patel SR, Priebat DA, Okuno SH, Samuels B, Fanucchi M, Harmon DC, Schuetze SM, Reinke D, Thall PF, Benjamin RS, Baker LH, Hensley ML: Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002[corrected]. J Clin Oncol 2007, 25:2755-2763.
• [11]Vermi W, Giurisato E, Lonardi S, Balzarini P, Rossi E, Medicina D, Bosisio D, Sozzani S, Pellegrini W, Doglioni C, Marchetti A, Rossi G, Pileri S, Facchetti F: Ligand-dependent activation of EGFR in follicular dendritic cells sarcoma is sustained by local production of cognate ligands. Clin Cancer Res 2013, 19:5027-5038.
• [12]Perry AM, Nelson M, Sanger WG, Bridge JA, Greiner TC: Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review. In Vivo 2013, 27:211-214.