International Journal of Pediatric Endocrinology | |
The vitamin D grey areas in pediatric primary care. Very low serum 25-hydroxyvitamin D levels in asymptomatic children living in northeastern Italy | |
Chiara Boscardin1  Daniela Toderini2  Stefano Mazzoleni3  | |
[1] MD, Borsista Clinica Pediatrica, Università di Padova, Padova, Italy;MD, Endocrinologa, Medico di Medicina Generale, ULSS 16 Regione Veneto, Padova, Italy;Correspondence address: Polistudio Pediatrico, via G. D'Annunzio 3/A, I-35028 Piove di Sacco (Padova), Italy | |
关键词: supplementation; insufficiency; deficiency; cholecalciferol; vitamin D; 25-Hydroxyvitamin D; | |
Others : 813560 DOI : 10.1186/1687-9856-2012-7 |
|
received in 2012-03-24, accepted in 2012-04-18, 发布年份 2012 | |
【 摘 要 】
The principal questions about the vitamin D topic are far to be resolved: in which children 25-hydroxyvitamin D blood testing is appropriate and how much cholecalciferol should be given in the absence of the test? Analyzing vitamin D status in a group of children cared by a "family pediatrician" in northeastern Italy we noted a high incidence of deficiency in asymptomatic preschool children without risk factors. As routine vitamin D testing is not recommended in the average risk population the supplementation with cholecalciferol represents a "grey area" mostly in pediatric primary care.
【 授权许可】
2012 Mazzoleni et al; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20140710005258324.pdf | 458KB | download |
【 参考文献 】
- [1]Bener A, Hoffmann GF: Nutritional Rickets among Children in a Sun Rich Country. Int J Pediatr Endocrinol 2010, 2010:410502. Epub 2010 Oct 27 BioMed Central Full Text
- [2]Mansbach M, Ginde AA, Camargo CA: Serum 25-Hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D? Pediatrics 2009, 124:1404-1410.
- [3]Rathi N, Rathi A: Vitamin D and child health in the 21st century. Indian Pediatr 2011, 48:619-625.
- [4]Holick MF: The D-lemma: To screen or not to screen for 25-Hydroxyvitamin D concentrations. Clin Chem 2010, 56:729-731.
- [5]Saintonge S, Bang H, Gerber LM: Implications of a new definition of vitamin D deficiency in a multiracial US adolescent population: the National Health and Nutrition Survey III. Pediatrics 2009, 123:797-803.
- [6]Lippi G, Montagnana M, Targher G: Vitamin D deficiency among Italian children [letter]. CMAJ 2007, 177:1529-1530.
- [7]Marrone G, Rosso I, Moretti R, Valent F, Romanello C: Is vitamin D status known among children living in Northern Italy? Eur J Nutr 2012, 51:143-149. [Epub 2011 May 4]
- [8]Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL: Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr 2011, 158:437-441. Epub 2010 Sep 26
- [9]Holick MF: Vitamin D deficiency. N Engl J Med 2007, 357:266-281.
- [10]Mutlu GY, Kusdal Y, Ozsu E, Cizmecioglu FM, Hatun S: Prevention of Vitamin D deficiency in infancy: daily 400 IU vitamin D is sufficient. Int J Pediatr Endocrinol 2011, 2011:4. Epub 2011 Jun 28 BioMed Central Full Text
- [11]Vieth R: Why the minimum desirable serum 25-hydroxyvitamin D level should be 75 nmol/L (30 ng/ml). Best Pract Res Clin Endocrinol Metab 2011, 25:681-691.
- [12]Abrams SA: Dietary Guidelines for Calcium and Vitamin D: A New Era. Pediatrics 2011, 127:566-568.
- [13]Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ: Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003, 77:204-210.