Isolated ACTH deficiency in self referred patients for LOH syndrome: two case reports

Reproductive medicine and biology

article

Yoshikazu Sato¹  Hitoshi Tanda¹  Hisao Nakajima¹  Toshikazu Nitta¹  Keigo Akagashi¹  Tatsuo Hanzawa¹  Musashi Tobe¹  Kazunori Haga¹  Kousuke Uchida¹  Ichiya Honma¹ 

[1] Department of Urology, Sanjukai Hospital

关键词: Adrenal insufficiency General malaise Hypotension Isolated ACTH deficiency LOH syndrome;   

DOI  :  10.1007/s12522-012-0121-1

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that most often causes infertility. It occurs due to the failure of folliculogenesis, thus causing non-ovulation. Letrozole is a 3rd generation drug of non-ste­roidal aromatase inhibitors, which can increase ovulation rates. Electroacupuncture is the insert­ion and manipu­lation of needles into acupunc­ture points (acu­points) that are selected speci­fically based on the meridian system and con­nected to the electrode stimulator. This study aimed to determine the differences of the effects of letrozole and letrozoleelectroacupuncture (letrozole-EA) on the improve­ment of folliculo­genesis in women with PCOS. Subjects and Method: This was an analytic observational study with a case-control design. This study was conducted at the Gynecology Polyclinic and Sekar Clinic, Dr. Moewardi Hos­pital, Surakarta. A sample of 30 infertile women aged 20-45 years was selected by fixed disease sampling. The criteria of the PCOS were deter­mined based on Rotterdam criteria. The depen­dent variable was the diameter of the follicle. The independent vari­ables were the administration of letrozole and letrozole-EA. Transvaginal ultra­sound of Voluson P6 was used to measure the folliculo­genesis. The data were analyzed by independent t-test. Results: On the second day after treatment, the diameter of the follicles in the letrozole-EA group (mean= 6.92; SD= 1.60) was bigger than the letrozole group (mean=5.66; SD=1.11), and it was statistically significant (p=0.004). Conclusion: Combination of letrozole and letrozole-EA therapy is more effective in increasing follicular diameter development than letrozole therapy only.

【 授权许可】

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