期刊论文详细信息
Journal of Molecular Signaling
Signaling in colon cancer stem cells
Adhip PN Majumdar1  Sanchita Roy2 
[1] Karmanos Cancer Centre, Wayne State University School of Medicine, Detroit, MI, 48201, USA;Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, 48201, USA
关键词: Hedgehog;    TGF-β;    Wnt;    Notch;    Cancer stem cell;    Colon cancer;   
Others  :  802892
DOI  :  10.1186/1750-2187-7-11
 received in 2012-05-30, accepted in 2012-07-11,  发布年份 2012
PDF
【 授权许可】

   
2012 Roy and Majumdar; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20140708032347872.pdf 320KB PDF download
Figure 1. 61KB Image download
【 图 表 】

Figure 1.

【 参考文献 】
  • [1]American Cancer Society: Colorectal Cancer Facts & Figures. Atlanta, Georgia: American Cancer Society; 2011–2013.
  • [2]Welch JP, Donaldson GA: The clinical correlation of an autopsy study of recurrent colorectal cancer. Ann Surg 1979, 189:496-502.
  • [3]Dean M, Fojo T, Bates S: Tumour stem cells and drug resistance. Nat Rev Cancer 2005, 5(4):275-284.
  • [4]Humphries A, Wright NA: Colonic crypt organization and Tumorigenesis. Nat Rev Cancer 2008, 8:415-424.
  • [5]Brittan M, Wright NA: Gastrointestinal stem cells. J Pathol 2002, 197:492-509.
  • [6]Cheng H, Leblond CP: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat 1974, 141:537-561.
  • [7]Willis ND, Przyborski SA, Hutchison CJ, Wilson RG: Colonic and colorectal cancer stem cells: progress in the search for putative biomarkers. J Anat 2008, 213:59-65.
  • [8]Virchow R: Editorial. Virchows Arch Pathol Anat Physiol Klin Med 1855, 3:23.
  • [9]Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Julio C, Minden M, Paterson B, Caliguiri MA, Dick JE: A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994, 367:645-648.
  • [10]Visvader JE, Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008, 8:755-768.
  • [11]O'Brien CA, Pollett A, Gallinger S, Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
  • [12]Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R: Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445(7123):111-115.
  • [13]Sanders MA, Majumdar AP: Colon cancer stem cells: implications in carcinogenesis. Front Biosci 2011, 16:1651-1662.
  • [14]Brabletz S, Schmalhofer O, Brabletz T: Gastrointestinal stem cells in development and cancer. J Pathol 2009, 217:307-317.
  • [15]Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS: Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 2009, 7:e1000121.
  • [16]Kolligs FT, Bommer G, Goke B: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 2002, 66:131-144.
  • [17]Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW: Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997, 275:1787-1790.
  • [18]Staal FJ, Luis TC, Tiemessen MM: WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol 2008, 8:581-593.
  • [19]Sugimura R, Li L: Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases. Birth Defects Res C Embryo Today 2010, 90(4):243-256.
  • [20]Komiya Y, Habas R: Wnt signal transduction pathways. Organogenesis 2008, 4:68-75.
  • [21]Gregorieff A, Pinto D, Begthel H, Destree O, Kielman M, Clevers H: Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 2005, 129:626-638.
  • [22]van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H: The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002, 111:241-250.
  • [23]Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y: Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992, 1:229-233.
  • [24]Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW: APC mutations occur early during colorectal tumorigenesis. Nature 1992, 359:235-237.
  • [25]Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D, et al.: Identification of FAP locus genes from chromosome 5q21. Science 1991, 253:661-665.
  • [26]Vermeulen L, Melo DSE, Van Der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP: Wnt activity defines colon cancer stem cellsand is regulated by the microenvironment. Nat Cell Biol 2010, 12:468-476.
  • [27]Dejmek J, Dejmek A, Safholm A, Sjolander A, Andersson T: Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res 2005, 65:9142-9146.
  • [28]Kanwar SS, Yu Y, Nautiyal J, Patel BB, Majumdar AP: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Mol Cancer 2010, 9:212. BioMed Central Full Text
  • [29]Massague J, Blain SW, Lo RS: TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 2000, 103(2):295-309.
  • [30]Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 1998, 95(6):779-791.
  • [31]Hoosein NM, McKnight MK, Levine AE, Mulder KM, Childress KE, Brattain DE, Brattain MG: Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor-beta 1. Exp Cell Res 1989, 181(2):442-453.
  • [32]Grady WM, Carethers JM: Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 2008, 135(4):1079-1099.
  • [33]Ilyas M, Efstathiou JA, Straub J, Kim HC, Bodmer WF: Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression. Proc Natl Acad Sci U S A 1999, 96(6):3087-3091.
  • [34]Xu Y, Pasche B: TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet 2007, 16(spec. no. 1):R14-R20.
  • [35]Tang Y, Katuri V, Srinivasan R, Fogt F, Redman R, Anand G, Said A, Fishbein T, Zasloff M, Reddy EP, Mishra B, Mishra L: Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. Cancer Res 2005, 65(10):4228-4237.
  • [36]Ohishi K, Varnum-Finney B, Flowers D, Anasetti C, Myerson D, Bernstein ID: Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1. Blood 2000, 95(9):2847-2854.
  • [37]Kopan R: Notch: a membrane-bound transcription factor. J Cell Sci 2002, 115(Pt 6):1095-1097.
  • [38]Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA: Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J 2006, 25:129-138.
  • [39]Katoh M: Notch signaling in gastrointestinal tract. Int J Oncol 2007, 30:247-251.
  • [40]Sander GR, Powell BC: Expression of notch receptors and ligands in the adult gut. J Histochem Cytochem 2004, 52:509-516.
  • [41]Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD: Control of endodermal endocrine development by Hes-1. Nat Genet 2000, 24:36-44.
  • [42]van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H: Notch ⁄ gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005, 435:959-963.
  • [43]Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S: Notch signals control the fate of immature progenitor cells in the intestine. Nature 2005, 435:964-968.
  • [44]Reedijk M, Odorcic S, Zhang H, Chetty R, Tennert C, Dickson BC, Lockwood G, Gallinger S, Egan SE: Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol 2008, 33:1223-1229.
  • [45]Ghaleb AM, Aggarwal G, Bialkowska AB, Nandan MO, Yang VW: Notch inhibits expression of the Kru¨ppel-like factor 4 tumor suppressor in the intestinal epithelium. Mol Cancer Res 2008, 6:1920-1927.
  • [46]Shields JM, Christy RJ, Yang VW: Identification and characterization of a gene encoding a gut-enriched KrA?ppel-like factor expressed during growth arrest. J Biol Chem 1996, 271:20009-20017.
  • [47]Chen X, Johns DC, Geiman DE, Geiman DE, Marban E, Dang DT, Hamlin G, Sun R, Yang VW: KrA?ppel-like factor 4 (gut-enriched KrA?ppel-like factor) inhibits cell proliferation by blocking G1 ⁄ S progression of the cell cycle. J Biol Chem 2001, 276:30423-30428.
  • [48]Ghaleb AM, McConnell BB, Nandan MO, Katz JP, Kaestner KH, Yang VW: Haploinsufficiency of Kru¨ppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res 2007, 67:7147-7154.
  • [49]Zhao W, Hisamuddin IM, Nandan MO, Babbin BA, Lamb NE, Yang VW: Identification of Kru¨ppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene 2004, 23:395-402.
  • [50]Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM: NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res 2010, 70:1469-1478.
  • [51]Ingham PW, Nakano Y, Seger C: Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 2011, 12(6):393-406.
  • [52]Varjosalo M, Taipale J: Hedgehog: functions and mechanisms. Genes Dev 2008, 22:2454-2472.
  • [53]Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ: A paracrine requirement forHedgehog signalling in cancer. Nature 2008, 455:406-410.
  • [54]Feldmann G, Dhara S, Fendrich V, et al.: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007, 67:2187-2196.
  • [55]Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA: The epithelial-mesenchymaltransition generates cells with properties of stem cells. Cell 2008, 133:704-715.
  • [56]Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, Ruiz i Altaba A: Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 2009, 1:338-351.
  • [57]Anderson EC, Hessman C, Levin TG, Monroe MM, Wong MH: The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response. Cancers (Basel) 2011, 3(1):319-339.
  • [58]Simone DFS, Mancuso P, Benfante A, Spina M, Iovino I, Dieli F, Giorgio S, Todaro M: Colon Cancer Stem Cells: Bench-to-Bedside—New Therapeutical Approaches in Clinical Oncology for Disease Breakdown. Cancers 2011, 3(2):1957-1974.
  文献评价指标  
  下载次数:16次 浏览次数:14次