Specific structure and unique function define the hemicentin

Cell & Bioscience

Williams B Isaacs⁷  Donald D Anthony¹  Guifang Yan⁷  Yuexin Pan¹  Edward Moharomd³  Odell B Jones⁵  Xin Zhou²  MengMeng Xu⁶  Xuehong Xu⁴ 

[1] School of Medicine, Case Western Reserve University, Baltimore, MD, USA;School of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, China;School of Public Health, Johns Hopkins University, Baltimore, MD, USA;Previous affiliation: School of Medicine, University of Maryland, Baltimore, MD 21201, USA;School of Medicine, University of North Carolina, Chapel Hill, NC, USA;Duke University Medical Center, Durham, NC, USA;School of Medicine, Johns Hopkins University, Baltimore, MD, USA

关键词: Mitosis;    Cell division;    Tissue/Organ architecture;    Embryogenesis;    Hemicentin;    Fibulin;    Extracellular matrix (ECM);   

Others  :  791606
DOI  :  10.1186/2045-3701-3-27

 received in 2012-12-14, accepted in 2013-04-24,  发布年份 2013

【 摘 要 】

Hemicentin has come a long way from when it was first identified in C. elegans as him-4 (High incidence of males). The protein is now a recognized player in maintaining the architectural integrity of vertebrate tissues and organs. Highly conserved hemicentin sequences across species indicate this gene’s ancient evolutionary roots and functional importance. In mouse, hemicentin is liberally distributed on the cell surface of many cell types, including epithelial cells, endothelial cells of the eye, lung, and uterus, and trophectodermal cells of blastocyst. Recent discoveries have uncovered yet another vital purpose of hemicentin 1. The protein also serves a unique function in mitotic cytokinesis, during which this extracellular matrix protein plays a key role in cleavage furrow maturation. Though understanding of hemicentin function has improved through new discoveries, much about this protein remains mysterious.

【 授权许可】

   
2013 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

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