Left-right asymmetric expression of dpp in the mantle of gastropods correlates with asymmetric shell coiling

EvoDevo

Kazuyoshi Endo⁵  Edi Gittenberger²  Takahiro Asami³  Tetsuhiro Kudoh¹  Isao Sarashina⁵  Davin HE Setiamarga⁵  Minoru Iijima⁴  Keisuke Shimizu⁵ 

[1] College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK;Netherlands Center for Biodiversity, Leiden, The Netherlands;Department of Biology, Shinshu University, Mastumoto, 390-0802, Japan;Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-0006, Japan;Department of Earth & Planetary Science, The University of Tokyo, 7-3-1 Hongo, Tokyo, 113-0033, Japan

关键词: Gastropods;    Shell coiling;    Decapentaplegic;    Left-right asymmetry;   

Others  :  806672
DOI  :  10.1186/2041-9139-4-15

 received in 2012-12-18, accepted in 2013-03-21,  发布年份 2013

【 摘 要 】

Background

Various shapes of gastropod shells have evolved ever since the Cambrian. Although theoretical analyses of morphogenesis exist, the molecular basis of shell development remains unclear. We compared expression patterns of the decapentaplegic (dpp) gene in the shell gland and mantle tissues at various developmental stages between coiled-shell and non-coiled-shell gastropods.

Results

We analyzed the expression patterns of dpp for the two limpets Patella vulgata and Nipponacmea fuscoviridis, and for the dextral wild-type and sinistral mutant lineage of the pond snail Lymnaea stagnalis. The limpets had symmetric expression patterns of dpp throughout ontogeny, whereas in the pond snail, the results indicated asymmetric and mirror image patterns between the dextral and sinistral lineages.

Conclusion

We hypothesize that Dpp induces mantle expansion, and the presence of a left/right asymmetric gradient of the Dpp protein causes the formation of a coiled shell. Our results provide a molecular explanation for shell, coiling including new insights into expression patterns in post-embryonic development, which should aid in understanding how various shell shapes are formed and have evolved in the gastropods.

【 授权许可】

   
2012 Shimizu et al.; licensee BioMed Central Ltd.

【 图 表 】

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