Specific IgE to fish extracts does not predict allergy to specific species within an adult fish allergic population

Clinical and Translational Allergy

André C Knulst²  Jonas Lidholm¹  Åsa Marknell deWitt¹  Carla AFM Bruijnzeel-Koomen²  Marjolein de Bruin-Weller²  Lidy Knigge²  Rob JB Klemans²  Karlijn JG Schulkes² 

[1] Thermo Fisher Scientific, Uppsala, Sweden;Department of Dermatology/Allergology, University Medical Center Utrecht, PO Box 85500, Utrecht 3508, GA the Netherlands

关键词: Specific IgE;    Sensitization;    Food allergy;    Fish species;    Fish allergy;   

Others  :  1092773
DOI  :  10.1186/2045-7022-4-27

 received in 2014-04-28, accepted in 2014-07-30,  发布年份 2014

【 摘 要 】

Background

Fish is an important cause of food allergy. Studies on fish allergy are scarce and in most cases limited to serological evaluation. Our objective was to study patterns of self-reported allergy and tolerance to different commonly consumed fish species and its correlation to IgE sensitization to the same species.

Methods

Thirty-eight adult fish allergic patients completed a questionnaire regarding atopy, age of onset and symptoms to 13 commonly consumed fish species in the Netherlands (pangasius, cod, herring, eel, hake, pollock, mackerel, tilapia, salmon, sardine, tuna, plaice and swordfish). Specific IgE to these fish extracts were analyzed by ImmunoCAP.

Results

Median age of onset of fish allergy was 8.5 years. Severe reactions were reported by the majority of patients (n = 20 (53%) respiratory and of these 20 patients, 6 also had cardiovascular symptoms). After diagnosis, 66% of the patients had eliminated all fish from their diet. Allergy to all species ever tried was reported by 59%. In relation to species ever tried, cod (84%) and herring (79%) were the most frequently reported culprit species while hake (57%) and swordfish (55%) were the least frequent. A positive sIgE (value ≥ 0.35 kU_A/L) to the culprit species ranged between 50% (swordfish) and 100% (hake). In tolerant patients, a negative sIgE (value < 0.35 kU_A/L) ranged from 0% (hake, pollock and swordfish) to 75% (sardine). For cod, the agreement between sIgE test results and reported allergy or tolerance was 82% and 25%, respectively. Sensitization to cod parvalbumin (Gad c 1) was present in 77% of all patients.

Conclusion

Serological cross-reactivity between fish species is frequent, but in a significant proportion of patients, clinical relevance appears to be limited to only certain species. A well-taken history or food challenge is required for discrimination between allergy to the different fish species.

【 授权许可】

   
2014 Schulkes et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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