Uterine mast cell tumor: a clinical and cytohistopathological study

Journal of Ovarian Research

Mehdi Pourzaer²  Hamed Masoudi⁴  Ehsan Hosseini⁷  Siamak Mohsenzadeh³  Soheil Javaherypour⁴  Mostafa Naderafif³  Mohammad Reza Hafezi Ahmadi¹  Mehdi Rashnavadi⁵  Javad Cheraghi⁷  Shahram Zehtabian⁶  Fariba Khaki²  Ali Mohammad Bahrami⁵ 

[1] Department of Pathology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran;Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran;Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran;Student of Veterinary Medicine, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran;Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran;Department of Physiology, Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran

关键词: Diagnosis;    Uterine;    Cytology;    Histopathology;    Mact cell tumor;   

Others  :  1151663
DOI  :  10.1186/s13048-014-0105-3

 received in 2014-08-17, accepted in 2014-10-27,  发布年份 2014

【 摘 要 】

Background

Mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. Further studies are suggested to determine the type of these cells which might be useful in the assessment of biological nature of the tumor and its future treatment modality. Few studies have evaluated mast cell infiltration in visceral tumors, especially uterine tumors.

Case presentation

In this study, age, sex, death rate, and histologic patterns were in agreement with those of previous reports on canine mast cell tumors. Cytopathology assays are widely used to prognosticate canine uterine mast cell tumors (MCT). There is limited information about these prognostic assays used on MCT that arise in the uterine. The anisocytosis and anisocytosis and giant cells were present in the tumor. Furthermore, the tumor had nuclear atypia with scattered multinucleated cells and prominent nucleoli and tumor were classified as poorly granulated. Under microscopic examination, we observed diffuse infiltration and proliferation of tumor cells from the uterine different area and the infiltrative characteristics and distribution patterns of neoplastic cells were observed. This tumor consisted of sheets and cords of uniform round cells with discrete cytoplasmic margins. Microscopically, the neoplastic masses were poorly-demarcated and lacked capsules and tumor cell usually showed a distinct cell boundary. Nevertheless, the neoplastic cells were located between collagen bundles forming small clusters and sheets and had large, centrally located, round to ovoid nuclei. In addition, eosinophils were scattered among the mast cells at the periphery of the masses. The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules.

Conclusion

Based on these findings, a diagnosis of poorly-differentiated mast cell tumor was made and data histologic grading was available for tumor. Neoplasm was poorly differentiated or gradeIII.

【 授权许可】

   
2014 Bahrami et al.; licensee BioMed Central Ltd.

【 图 表 】

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