Angiosarcoma of the proximal humerus: a case report and review of the literature

Journal of Medical Case Reports

Ryota Teshima¹  Koji Endo¹  Hideki Yamashita¹ 

[1] Department of Orthopedic Surgery, Faculty of Medicine, Tottori University, 36-1 Nishi-machi, Yonago, Tottori, 683-8504, Japan

关键词: Surgery;    Chemotherapy;    Proximal humerus;    Angiosarcoma;   

Others  :  1195344
DOI  :  10.1186/1752-1947-6-347

 received in 2012-07-26, accepted in 2012-09-12,  发布年份 2012

【 摘 要 】

Introduction

Angiosarcoma of bone is an uncommon primary bone neoplasm that is composed of tumor cells that show endothelial differentiation. This is an aggressive malignancy characterized by frequent local recurrence and distant metastases. The majority of patients die within one year of diagnosis, and this shows that angiosarcoma of bone is an aggressive high-grade tumor.

Case presentation

We present the case of a 65-year-old Japanese woman who had primary angiosarcoma of the proximal humerus with a pathological fracture. An open biopsy confirmed a diagnosis of primary angiosarcoma of bone. Our patient was treated with neoadjuvant chemotherapy and wide resection. One month after surgery, she developed multifocal distant metastasis to her liver and spleen.

Conclusions

Angiosarcoma of the humerus is extremely rare. Radiographically, there is no specific finding associated with angiosarcoma of bone as opposed to other malignant bone tumors. The cornerstone of treatment is en bloc resection followed by as much adjuvant radiation therapy as possible. However, the role of chemotherapy remains undefined, and better systemic agents are clearly needed.

【 授权许可】

   
2012 Yamashita et al.; licensee BioMed Central Ltd.

【 图 表 】

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