Mst1 and Mst2 kinases: regulations and diseases

Cell & Bioscience

Lanfen Chen¹  Dawang Zhou¹  Jing Tian¹  Funiu Qin¹ 

[1] State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiang’An South Road, Xiang’An District, Xiamen, Fujian 361102, China

关键词: Immune diseases;    Cancer;    YAP;    Reactive oxygen species;    Mst2;    Mst1;    The Hippo pathway;   

Others  :  791575
DOI  :  10.1186/2045-3701-3-31

 received in 2013-06-21, accepted in 2013-08-03,  发布年份 2013

【 摘 要 】

The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development. Mst1/2 can be activated by cellular stressors and the activation of Mst1/2 might enforce a feedback stimulation system to regulate oxidant levels through several mechanisms, in which regulation of cellular redox state might represent a tumor suppressor function of Mst1/2. As in Drosophila, murine Mst1/Mst2, in a redundant manner, negatively regulate the Yorkie ortholog YAP in multiple organs, although considerable diversification in the pathway composition and regulation is observed in some of them. Generally, loss of both Mst1 and Mst2 results in hyperproliferation and tumorigenesis that can be largely negated by the reduction or elimination of YAP. The Hippo pathway integrates with other signaling pathways e.g. Wnt and Notch pathways and coordinates with them to impact on the tumor pathogenesis and development. Furthermore, Mst1/2 kinases also act as an important regulator in immune cell activation, adhesion, migration, growth, and apoptosis. This review will focus on the recent updates on those aspects for the roles of Mst1/2 kinases.

【 授权许可】

   
2013 Qin et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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