Evolutionary insights into postembryonic development of adult intestinal stem cells

Cell & Bioscience

Yun-Bo Shi²  Atsuko Ishizuya-Oka¹ 

[1] Department of Biology, Nippon Medical School, Kawasaki, Kanagawa 211-0063, Japan;Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism (PCRM), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, 20892, USA

关键词: thyroid hormone;    amphibian metamorphosis;    mammalian suckling-to-weaning transition;    adult stem cell;   

Others  :  793769
DOI  :  10.1186/2045-3701-1-37

 received in 2011-11-04, accepted in 2011-11-16,  发布年份 2011

【 摘 要 】

In the adult vertebrate intestine, multi-potent stem cells continuously generate all of the epithelial cells throughout the adulthood. While it has long been known that the frog intestine is formed via the development of adult intestinal stem cells during thyroid hormone (TH)-dependent metamorphosis, the basic structure of the adult intestine is formed by birth in mammals and it is unclear if the subsequent maturation of the intestine involves any changes in the intestinal stem cells. Two recent papers showing that B lymphocyte-induced maturation protein 1 (Blimp1) regulates postnatal epithelial stem cell reprogramming during mouse intestinal maturation support the model that adult intestinal stem cells are developed during postembryonic development in mammals, in a TH-dependent process similar to intestinal remodeling during amphibian metamorphosis. Since the formation of the adult intestine in both mammals and amphibians is closely associated with the adaptation from aquatic to terrestrial life during the peak of endogenous TH levels, the molecular mechanisms by which the adult stem cells are developed are likely evolutionally conserved.

【 授权许可】

   
2011 Ishizuya-Oka and Shi; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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