The burden of mental health in lymphatic filariasis

Infectious Diseases of Poverty

David H. Molyneux¹  Charles Mackenzie²  Thanh G.N. Ton³ 

[1] LSTM NTDs, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK;Filariasis Programmes Support Unit, Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK;Precision Health Economics, 555 12 th Avenue, Suite 1650, Oakland 94607, CA, USA

关键词: Caregivers;    Filariasis morbidity;    DALYS;    Global burden of disease;    Mental health;    Lymphatic filariasis;   

Others  :  1223365
DOI  :  10.1186/s40249-015-0068-7

 received in 2015-05-29, accepted in 2015-07-20,  发布年份 2015

【 摘 要 】

Background

Neglected Tropical Diseases (NTDs) afflict around one billion individuals in the poorest parts of the world with many more at risk. Lymphatic filariasis is one of the most prevalent of the infections and causes significant morbidity in those who suffer the clinical conditions, particularly lymphedema and hydrocele. Depressive illness has been recognised as a prevalent disability in those with the disease because of the stigmatising nature of the condition. No estimates of the burden of depressive illness of any neglected tropical disease have been undertaken to date despite the recognition that such diseases have major consequences for mental health not only for patients but also their caregivers.

Methods

We developed a mathematical model to calculate the burden of Disability- Adjusted Life Years (DALY) attributable to depressive illness in lymphatic filariasis and that of their caregivers using standard methods for calculating DALYs. Estimates of numbers with clinical disease was based on published estimates in 2012 and the numbers with depressive illness from the available literature.

Results

We calculated that the burden of depressive illness in filariasis patients was 5.09 million disability-adjusted life years (DALYs) and 229,537 DALYs attributable to their caregivers. These figures are around twice that of 2.78 million DALYs attributed to filariasis by the Global Burden of Disease study of 2010.

Conclusions

Lymphatic filariasis and other neglected tropical diseases, notably Buruli Ulcer, cutaneous leishmaniasis, leprosy, yaws, onchocerciasis and trachoma cause significant co morbidity associated with mental illness in patients. Studies to assess the prevalence of the burden of this co-morbidity should be incorporated into any future assessment of the Global Burden of neglected tropical diseases. The prevalence of depressive illness in caregivers who support those who suffer from these conditions is required. Such assessments are critical for neglected tropical diseases which have such a huge global prevalence and thus will contribute a significant burden of co-morbidity attributable to mental illness.

【 授权许可】

   
2015 Ton et al.

【 参考文献 】

• [1]Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al.: Disability-adjusted life years (Dalys) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012, 380:2197-223.
• [2]Hotez PJ, Alvarado M, Basanez MG, Bolliger I, et al.: The global burden of disease study 2010: Interpretation and implications for the neglected tropical diseases. PLOS NTD 2014, 8:e 2865.
• [3]Litt E, Baker MC, Molyneux DH: Neglected tropical diseases and mental health: a perspective on comorbidity. Trends Parasitol 2012, 28:195-201.
• [4]Weiss M: Stigma and the social burden of neglected tropical diseases. PLOS NTD 2008, 2:e237.
• [5]Perera M, et al.: Neglected patients with a neglected disease?A qualitative study of lymphatic filariasis. PLoS NTD 2008, 1:128.
• [6]Hotez PJ, Fenwick A, Savioli L, Molyneux DH: Rescuing the bottom billion through control of neglected tropical diseases. Lancet 2009, 373:1570-1575.
• [7]Braich PS, et al.: Burden and depression in the caregivers of blind patients in India. Ophthalmology 2012, 119:221-226.
• [8]Orner P: Psychological impacts on caregivers of people living with AIDS. AIDS Care 2006, 18:236-240.
• [9]Chang H, et al.: Impact of mental health and caregiver burden on family caregivers’ physical health. Arch Gerontol Geriatr 2010, 50:267-271.
• [10]Thompson CA, et al.: Systematic review of information and support interventions for caregivers of people with dementia. BMC Geriatr 2007, 7:18. BioMed Central Full Text
• [11]World Health Organization: Lymphatic Filariasis: Managing Morbidity and Preventing Disability. An aide memoire for national programme managers. Geneva, Switzerland: World Health Organisation; 2013.
• [12]Suma TK, et al.: A qualitative study of the perceptions, practices and socio–psychological suffering related to chronic brugian filariasis in Kerala, southern India. Annals Trop Med Parasitol 2003, 97:839-845.
• [13]Richard SA, et al.: A survey of treatment practices and burden of lymphoedema in Togo. Trans Roy Soc Trop Med Hyg 2007, 101:391-397.
• [14]Wijesinghe RS, et al.: Physical disability and psychosocial impact due to chronic filarial lymphoedema in Sri Lanka. Filaria J 2007, 6:4. BioMed Central Full Text
• [15]Koji Kanda, MSc thesis,  The quality of life among lymphedema patients due to lymphatic filariasis in three rural towns in Haiti. University of South Florida; 2004.. http://scholarcommons.usf.edu/etd/115 webcite
• [16]Mousley E, Deribe K, Tamiru A, Tomczyk S, Hanlon C, Davey G: Mental distress and podoconiosis in Northern Ethiopia: a comparative cross-sectional study. Int Health 2015, 7:16-25.
• [17]Salomon JA, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, et al.: Common values in assessing health outcomes from disease and injury: Disability weights measurement study for the global burden of disease study 2010. Lancet 2012, 380:2129-43.
• [18]Ferrari A, Charlson FJ, Norman RE, Patten SB, Freedman G, et al.: Burden of depressive disorders by country, sex, age and year:findings from the global Burden of Disease Study 2010. PLoS Med 2013., 10Article ID e1001547
• [19]Ramaiah K: Ottesen EA Progress and imapct of 13 years of the Global Programme to Eliminate Lymphatic Filariasis on reducing the burden of filarial disease. PLOS NTD 2014, 8:e3319.
• [20]World Health Organization: Global Programme to Eliminate Lymphatic Filariasis: progress report Wkly Epidemiol Rec 2013, 89:409-420.
• [21]Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ: Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of disease study. Lancet 2013, 382:1575-1586.
• [22]Eaton WW, Martins SS, Nestadt G, Bienvenu OJ, Clarke D, Alexandre P: The Burden of mental disorders. Epidemiol Rev 2008, 30:1-14.