Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population

European Journal of Medical Research

Minling Chen¹  Shunguo Zhang¹  Qingchuan Liao²  Xiaolei Li¹ 

[1] Department of Pharmacy, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, 1678 Dongfang Road, Pudong, Shanghai 200127, China;Department of Pharmacy, Nanjing Children’s Hospital, Nanjing Medical University, Nanjing 210008, China

关键词: Acute lymphoblastic leukemia;    Gene polymorphism;    A1298C;    C677T;    Methylenetetrahydrofolate reductase (MTHFR);   

Others  :  817634
DOI  :  10.1186/2047-783X-19-5

 received in 2013-08-10, accepted in 2014-01-13,  发布年份 2014

【 摘 要 】

Background

The aim of this study was to investigate the relationship between the polymorphisms of the methylenetetrahytrofolate reductase (MTHFR) gene and susceptibility to childhood acute lymphoblastic leukemia (ALL).

Methods

A case–control study was conducted among 98 children with ALL and 93 age- and sex- matched non-ALL controls. Genotyping of MTHFR C677T and A1298C polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The odds ratios (ORs) of MTHFR genotypes were used to assess the associations of these polymorphisms with childhood ALL susceptibility.

Results

No significant differences were observed for frequencies of the 677CC, 677CT and 677TT genotypes between patients and controls. Frequencies of the 1298AA, 1298 AC and 1298CC genotypes between the two groups were significantly different. The risk of ALL with the 1298C allele carriers (AC + CC) was elevated by 1.1 times compared with the AA genotype [OR = 2.100; 95% CI (1.149; 3.837); P = 0.015].

Conclusions

The MTHFR A1298C polymorphism is associated with susceptibility to childhood ALL in the Chinese population.

【 授权许可】

   
2014 Li et al.; licensee BioMed Central Ltd.

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