Inflammatory myofibroblastic tumor of the bladder – an unexpected case coexisting with an ovarian teratoma

Diagnostic Pathology

Marek Ciepiela¹  Paweł Właszczuk²  Piotr Paleń²  Janusz Ryś³  Zuzanna Dobrosz² 

[1] Department of Obstetrics and Gynaecology, City Hospital No 2, Jastrzębie Zdrój, Poland;Department of Histopathology, Medical University of Silesia, Medyków Street 18, Katowice 40-754, Poland;Department of Tumour Pathology, Centre of Oncology – Maria Skłodowska-Curie Memorial Institute, Cracow Branch, Gancarska Street 11, Krakow 31-115, Poland

关键词: Fish analysis;    Immunohistochemistry;    Bladder neoplasm;    Inflammatory Myofibroblastic Tumor;   

Others  :  870263
DOI  :  10.1186/1746-1596-9-138

 received in 2014-04-09, accepted in 2014-05-21,  发布年份 2014

【 摘 要 】

Inflammatory myofibroblastic tumors (IMTs) mainly occur in children and young adults, usually in the first two decades of life. IMT-type tumors belong to neoplasms of an intermediate biologic potential with considerable rate of local recurrence and in some cases that able to create metastases. Presented case is the first IMT coexisting with the other neoplasm. In our paper we are going to present a peculiar case of an IMT of the bladder coexisting with an ovarian teratoma, and to discuss its pathogenesis, histological picture and differential diagnosis. A 19-year-old female was admitted to the Gynecological Department and during the surgery, two independent, non-adjacent tumors were found. To settle the diagnosis, a FISH examination with the ALK1 break apart probe was carried out. It confirmed the rearrangement of the chromosome 2p23. Morphologic and immunophenotypic similarities between an IMT and other malignant tumors of the bladder may lead to diagnostic errors and an unnecessary radical cystectomy as a result. The therapy of choice is only total excision of the tumor.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1937487606122622

【 授权许可】

   
2014 Dobrosz et al.; licensee BioMed Central Ltd.

【 图 表 】

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