Sensory and motor secondary symptoms as indicators of brain vulnerability

Journal of Neurodevelopmental Disorders

Yulia Golland²  Michael Davidovitch¹  Nava Levit-Binnun² 

[1] Tel Aviv Maccabi Healthcare Services, 27 Hamered St., Tel Aviv 68125, Israel;Interdisciplinary Center (IDC), Sagol Unit for Applied Neuroscience, School of Psychology, POB 167, Herzliya 46150, Israel

关键词: Vulnerability;    Sensory;    Secondary symptoms;    Resilience;    Networks;    Network neuroscience;    Motor;   

Others  :  806029
DOI  :  10.1186/1866-1955-5-26

 received in 2013-02-13, accepted in 2013-09-04,  发布年份 2013

【 摘 要 】

In addition to the primary symptoms that distinguish one disorder from the next, clinicians have identified, yet largely overlooked, another set of symptoms that appear across many disorders, termed secondary symptoms. In the emerging era of systems neuroscience, which highlights that many disorders share common deficits in global network features, the nonspecific nature of secondary symptoms should attract attention. Herein we provide a scholarly review of the literature on a subset of secondary symptoms––sensory and motor. We demonstrate that their pattern of appearance––across a wide range of psychopathologies, much before the full-blown disorder appears, and in healthy individuals who display a variety of negative symptoms––resembles the pattern of appearance of network abnormalities. We propose that sensory and motor secondary symptoms can be important indicators of underlying network aberrations and thus of vulnerable brain states putting individuals at risk for psychopathology following extreme circumstances.

【 授权许可】

   
2013 Levit-Binnun et al.; licensee BioMed Central Ltd.

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