Caloric restriction increases ratio of estrogen to androgen receptors expression in murine ovaries - potential therapeutic implications

Journal of Ovarian Research

Mariusz Z. Ratajczak²  Katarzyna Grymuła³  Marta Grabowska¹  Katarzyna Piotrowska³  Maria Laszczyńska¹  Sylwia Słuczanowska-Głąbowska³ 

[1] Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, Szczecin, 71-210, Poland;Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, Ky, USA;Department of Physiology Pomeranian Medical University, Powstańców Wielkopolskich 72, Szczecin, 70-111, Poland

关键词: Caloric restriction;    Estrogen receptors;    Androgen receptor;    Mice;    Ovary;   

Others  :  1224161
DOI  :  10.1186/s13048-015-0185-8

 received in 2015-01-28, accepted in 2015-08-04,  发布年份 2015

【 摘 要 】

Both estrogens and androgens are involved in the development and normal functioning of the ovaries. It is also known that ovarian function is regulated by diet. The goal of this study was to estimate the expression of sex hormone receptors in ovaries of mice that were on a 9-month caloric restriction (alternate-day feeding) as compared to normal control animals fed ad libitum. We found that prolonged caloric restriction in mouse ovaries led to increased expression of estrogen receptors (ERs) but did not affect expression of the androgen receptor (AR). This increase in ER:AR ration as result of caloric restriction may lead to higher sensitivity to estrogens and upon return to normal diet may increase ovulation. Thus our observation shed more light on a role of beneficial effect of calorie restriction on female reproduction.

【 授权许可】

   
2015 Słuczanowska-Głąbowska et al.

【 图 表 】

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