The Effects of Sex Protein Receptors and Sex Steroid Hormone Gene Polymorphisms on Breast Cancer Risk

National Medical Association. Journal

PourandokhtFarhanghianM.Sc.¹  SomayehJahandoostM.Sc.¹  SakinehAbbasi² 

[1] Department of Genetics and Molecular Medicine, Zanjan University of Medical Sciences, Iran;School of Allied Medicine, Tehran University of Medical Sciences, Tehran, 14177, Iran

关键词: Breast cancer;    Polymorphism;    Sex steroid metabolic enzyme;    Estrogen receptors;   

DOI  :  10.1016/j.jnma.2017.02.003

学科分类：医学（综合）

来源: Elsevier

【 摘 要 】

Breast cancer is a common disease and a major cause of death among women throughout the world. Various genes are believed to be involved in the initiation and progression of the disease. Some polymorphisms of these genes increase susceptibility to breast cancer in particular ethnicities. This study used electronic literature search to review the effects of different sex steroid hormone gene polymorphisms on breast cancer risk. Our findings indicated that some polymorphisms in estrogen receptor alpha (ER-α), ER-β, progesterone receptor (PGR), pregnane X receptor (PXR), and cytochrome P450 enzymes (CYPs) affected breast cancer susceptibility, especially in African American women.

【 授权许可】

Unknown