Acquired hemophagocytic syndrome related to parainfluenza virus infection: case report

Journal of Medical Case Reports

Mauricio Sarmiento²  Javier Pilcante¹  Nicole Beffermann² 

[1] Universidad Católica de la Santísima Concepción de Chile, Concepción, Chile;Department of Internal Medicine and Hematology and Oncology, Pontificia Universidad Católica de Chile, Lira 85 4to Piso, Santiago, Chile

关键词: Parainfluenza virus;    Hemophagocytic syndrome;    Etoposide;   

Others  :  1180762
DOI  :  10.1186/s13256-015-0552-5

 received in 2014-11-09, accepted in 2015-02-20,  发布年份 2015

【 摘 要 】

Introduction

We present the case of a patient with acquired hemophagocytic syndrome secondary to parainfluenza virus infection, a complication that has not, to the best of our knowledge, been previously reported.

Case presentation

A 33-year-old Chilean man with fever secondary to parainfluenza 2 virus infection developed progressive cholestasis, hepatosplenomegaly, cytopenia and an increased ferritin level (>2000IU/L). A bone marrow analysis showed hemophagocytosis. Our patient received HLH-94 chemotherapy, and he achieved complete and sustained remission after a two-year follow-up, without the need for hematopoietic stem cell transplantation.

Conclusion

Hemophagocytic syndrome is a severe disease with high mortality. A high index of suspicion is essential to improve survival. A viral etiology is frequent and although Epstein-Barr virus is the most frequently associated, other viruses like parainfluenza can cause this disease.

【 授权许可】

   
2015 Beffermann et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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