Exercise-induced hippocampal anti-inflammatory response in aged rats

Journal of Neuroinflammation

Ricardo Mario Arida²  Maria da Graça Naffah-Mazzacoratti⁴  Esper Abrão Cavalheiro⁴  Fulvio Alexandre Scorza⁴  Renato Arruda Mortara¹  Priscila Santos Rodrigues Simões⁴  Sérgio Gomes da Silva³ 

[1] Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Zip Code 04023-900, Brazil;Departamento de Fisiologia, Universidade Federal de São Paulo, Rua Botucatu 862, Ed. Ciências Biomédicas, 5 andar. Vila Clementino, São Paulo, SP, Zip Code 04023-900, Brazil;Faculdade do Clube Náutico Mogiano, Zip Code 08773-000,, Mogi das Cruzes, Brazil;Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Zip Code 04023-900, Brazil

关键词: Inflammation;    Cytokine;    Plasticity;    Aging;    Brain;    Treadmill;    Exercise;   

Others  :  1159974
DOI  :  10.1186/1742-2094-10-61

 received in 2013-02-11, accepted in 2013-04-12,  发布年份 2013

【 摘 要 】

Aging is often accompanied by cognitive decline, memory impairment and an increased susceptibility to neurodegenerative disorders. Most of these age-related alterations have been associated with deleterious processes such as changes in the expression of inflammatory cytokines. Indeed, higher levels of pro-inflammatory cytokines and lower levels of anti-inflammatory cytokines are found in the aged brain. This perturbation in pro- and anti-inflammatory balance can represent one of the mechanisms that contribute to age-associated neuronal dysfunction and brain vulnerability. We conducted an experimental study to investigate whether an aerobic exercise program could promote changes in inflammatory response in the brains of aged rats. To do so, we evaluated the levels of tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL1β), interleukin 6 (IL6) and interleukin 10 (IL10) in the hippocampal formation of 18 month old rats that underwent treadmill training over 10 consecutive days. Quantitative immunoassay analyses showed that the physical exercise increased anti-inflammatory cytokine levels IL10 in the hippocampal formation of aged rats, when compared to the control group. The hippocampal levels of pro-inflammatory cytokines IL1β, IL6 and TNFα were not statistically different between the groups. However, a significant reduction in IL1β/IL10, IL6/IL10 and TNFα/IL10 ratio was observed in the exercised group in relation to the control group. These findings indicate a favorable effect of physical exercise in the balance between hippocampal pro- and anti-inflammatory during aging, as well as reinforce the potential therapeutic of exercise in reducing the risk of neuroinflammation-linked disorders.

【 授权许可】

   
2013 Gomes da Silva et al.; licensee BioMed Central Ltd.

【 图 表 】

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