Effects of ethanol on immune response in the brain: region-specific changes in aged mice

Journal of Neuroinflammation

Paul D Drew¹  Jihong Xu¹  Jennifer Walker Johnson¹  Gail Wagoner¹  James C Douglas¹  Kevin D Phelan¹  Cynthia JM Kane¹ 

[1] Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Slot 846, Biomedical Research Building II, Room 563-2, 4301 W Markham Street, Little Rock, AR 72205, USA

关键词: Inflammation;    Ethanol;    Cytokine;    Chemokine;    Brain;    Aging;   

Others  :  1159963
DOI  :  10.1186/1742-2094-10-66

 received in 2013-03-08, accepted in 2013-05-08,  发布年份 2013

【 摘 要 】

Background

Alcohol abuse has dramatic effects on the health of the elderly. Recent studies indicate that ethanol increases immune activity in younger animals and that some of these proinflammatory molecules alter alcohol consumption and addiction. However, the effects of alcohol on immune activation in aged animals have not been thoroughly investigated.

Findings

We compared the effects of ethanol on chemokine and cytokine expression in the hippocampus, cerebellum, and cerebral cortex of aged C57BL/6 mice. Mice were treated via gavage with 6 g/kg ethanol for 10 days and tissue was harvested 1 day post-treatment. Ethanol selectively increased mRNA levels of the chemokine (C-C motif) ligand 2/monocyte chemotactic protein-1 in the hippocampus and cerebellum, but not in the cortex of aged mice relative to control animals. In this paradigm, ethanol did not affect mRNA levels of the cytokines IL-6 or TNF-α in any of these brain regions in aged animals.

Conclusions

Collectively, these data indicate a region-specific susceptibility to ethanol regulation of neuroinflammatory and addiction-related molecules in aged mice. These studies could have important implications concerning alcohol-induced neuropathology and alcohol addiction in the elderly.

【 授权许可】

   
2013 Kane et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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