Examination of mechanisms (E-MECHANIC) of exercise-induced weight compensation: study protocol for a randomized controlled trial

Trials

Corby K Martin²  Timothy S Church²  Melissa Harris²  Shannon Cocreham²  Neil M Johannsen¹  Catrine Tudor-Locke²  Jennifer C Rood²  Conrad P Earnest²  William D Johnson²  Candice A Myers² 

[1] School of Kinesiology, College of Human Sciences & Education, Louisiana State University, 112 Long Fieldhouse, Baton Rouge, LA 70803, USA;Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA

关键词: Weight loss;    Randomized controlled trial;    Exercise training;    Energy intake;    Energy expenditure;    Compensation;   

Others  :  805181
DOI  :  10.1186/1745-6215-15-212

 received in 2014-01-26, accepted in 2014-05-20,  发布年份 2014

【 摘 要 】

Background

Weight loss induced only by exercise is frequently less than expected, possibly because of compensatory changes in energy intake and/or energy expenditure. The purpose of the Examination of Mechanisms (E-MECHANIC) of Exercise-Induced Weight Compensation trial is to examine whether increased energy intake and/or reduced spontaneous activity or energy expenditure (outside of structured exercise) account for the less than expected, exercise-associated weight loss.

Methods/Design

E-MECHANIC is a three-arm, 6-month randomized (1:1:1) controlled trial. The two intervention arms are exercise doses that reflect current recommendations for (1) general health (8 kcal/kg body weight per week (8 KKW), about 900 kcal/wk) and (2) weight loss (20 KKW, about 2,250 kcal/wk). The third arm, a nonexercise control group, will receive health information only. The sample will include a combined total of 198sedentary, overweight or obese (body mass index: ≥25 kg/m² to ≤45 kg/m²) men and women ages 18 to 65 years. The exercise dose will be supervised and tightly controlled in an exercise training laboratory. The primary outcome variables are energy intake, which will be measured using doubly labeled water (adjusted for change in energy stores) and laboratory-based food intake tests, and the discrepancy between expected weight loss and observed weight loss. Secondary outcomes include changes in resting metabolic rate (adjusted for change in body mass), activity levels (excluding structured exercise) and body composition. In an effort to guide the development of future interventions, the participants will be behaviorally phenotyped and defined as those who do compensate (that is, fail to lose the amount of weight expected) or do not compensate (that is, lose the amount of weight expected or more).

Discussion

In this study, we will attempt to identify underlying mechanisms to explain why exercise elicits less weight loss than expected. This information will guide the development of interventions to increase exercise-induced weight loss and maximize weight loss retention and related health benefits.

Trial registration

ClinicalTrials.gov ID: NCT01264406 (registration date: 20 December 2010).

【 授权许可】

   
2014 Myers et al.; licensee BioMed Central Ltd.

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