Remodeling of calcium signaling in tumor progression

Journal of Biomedical Science

Meng-Ru Shen³  Wen-Tai Chiu¹  Ying-Ting Chen²  Yih-Fung Chen⁴ 

[1] Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan;Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan;Department of Obstetrics & Gynecology, National Cheng Kung University Hospital, Tainan, 704, Taiwan;Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan

关键词: Transient receptor potential (TRP) channels;    Orai;    Stromal interaction molecule (STIM);    Ca²⁺ homeostasis;    Migration;   

Others  :  824085
DOI  :  10.1186/1423-0127-20-23

 received in 2013-02-18, accepted in 2013-04-08,  发布年份 2013

【 摘 要 】

Intracellular Ca²⁺ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca²⁺ homeostasis has been suggested as an important event in driving the expression of the malignant phenotypes, such as proliferation, migration, invasion, and metastasis. Cell migration is an early prerequisite for tumor metastasis that has a significant impact on patient prognosis. During cell migration, the exquisite spatial and temporal organization of intracellular Ca²⁺ provides a rapid and robust way for the selective activation of signaling components that play a central role in cytoskeletal reorganization, traction force generation, and focal adhesion dynamics. A number of known molecular components involved in Ca²⁺ influx pathways, including stromal interaction molecule (STIM)/Orai-mediated store-operated Ca²⁺ entry (SOCE) and the Ca²⁺-permeable transient receptor potential (TRP) channels, have been implicated in cancer cell migration and tumor metastasis. The clinical significance of these molecules, such as STIM proteins and the TRPM7 channel, in tumor progression and their diagnostic and prognostic potentials have also been demonstrated in specific cancer types. In this review, we summarize the recent advances in understanding the important roles and regulatory mechanisms of these Ca²⁺ influx pathways on malignant behaviors of tumor cells. The clinical implications in facilitating current diagnostic and therapeutic procedures are also discussed.

【 授权许可】

   
2013 Chen et al.; licensee BioMed Central Ltd.

【 图 表 】

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