P68 RNA helicase as a molecular target for cancer therapy

Journal of Experimental & Clinical Cancer Research

Chun-Meng Shi¹  Xin-Ze Ran¹  Li Tan¹  Ya-Shu Li¹  Zi-Chen Yang¹  Liu Cao¹  Ting-Yu Dai¹ 

[1] Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Department of Preventive Medicine, Third Military Medical University, Chongqing 400038, China

关键词: Transcriptional co-activator;    Molecular target;    p68;    RNA helicase;   

Others  :  1161159
DOI  :  10.1186/s13046-014-0064-y

 received in 2014-05-14, accepted in 2014-07-16,  发布年份 2014

【 摘 要 】

The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and RNA helicase ability, p68 can also function as a co-activator for transcription factors such as estrogen receptor alpha, tumor suppressor p53 and beta-catenin. More than that, post-translational modification of p68 including phosphorylation, acetylation, sumoylation, and ubiquitylation can regulate the coactivation effect. Furthermore, aberrant expression of p68 in cancers highlights that p68 plays an important role for tumorgenesis and development. In this review, we briefly introduce the function and modulation of p68 in cancer cells, and put forward envisagement about future study about p68.

【 授权许可】

   
2014 Dai et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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