MicroRNA-binding site polymorphisms in hematological malignancies

Journal of Hematology & Oncology

Agnieszka Dzikiewicz-Krawczyk¹ 

[1] Institute of Human Genetics, Polish Academy of Sciences, Strzeszy?ska 32, Pozna? 60-479, Poland

关键词: Prognosis;    Risk;    Myeloma;    Lymphoma;    Leukemia;    miRNA-binding site polymorphism;    microRNA;   

Others  :  1144170
DOI  :  10.1186/s13045-014-0083-3

 received in 2014-09-18, accepted in 2014-11-06,  发布年份 2014

【 摘 要 】

Dysregulation of microRNA networks has been implicated in hematological malignancies. One of the reasons for disturbed miRNA-mediated regulation are polymorphisms in miRNA-binding sites (miRSNPs), which alter the strength of miRNA interaction with target transcripts. In the recent years the first findings of miRSNPs associated with risk and prognosis in hematological malignancies have been reported. From the studies described in this review miRSNPs not only emerge as novel markers of risk and prognosis but can also lead to better understanding of the role of miRNAs in regulating gene expression in health and disease.

【 授权许可】

   
2014 Dzikiewicz-Krawczyk; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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