Spatial epidemiology of dry eye disease: findings from South Korea

International Journal of Health Geographics

Hyeon Chang Kim³  Jong Suk Song¹  Hyung Keun Lee⁴  Na Hyun Kim²  Sun-Bi Um² 

[1] Department of Ophthalmology, Korea University College of Medicine, Seoul, South Korea;Department of Public Health, Yonsei University Graduate School, Seoul, South Korea;Department of Preventive Medicine, Yonsei University College of Medicine, 50-1Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea;Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea

关键词: Spatial epidemiology;    Prevalence;    Meteorological factors;    Dry eye disease;    Air pollutants;   

Others  :  1141629
DOI  :  10.1186/1476-072X-13-31

 received in 2014-05-31, accepted in 2014-08-11,  发布年份 2014

【 摘 要 】

Background

DED rate maps from diverse regions may allow us to understand world-wide spreading pattern of the disease. Only few studies compared the prevalence of DED between geographical regions in non-spatial context. Therefore, we examined the spatial epidemiological pattern of DED prevalence in South Korea using a nationally representative sample.

Methods

We analyzed 16,431 Korean adults aged 30 years or older of the 5th Korea National Health and Nutrition Examination Survey. DED was defined as previously diagnosed by an ophthalmologist as well as symptoms experienced. Multiple logistic regression analysis was used to assess the spatial pattern in the prevalence of DED, and effects of environmental factors.

Results

Among seven metropolitan cities and nine provinces, three metropolitan cities located in the southeast of Korea revealed the highest prevalence of DED. After adjusting for sex, age and survey year, people living in urban areas had higher risk of having DED. Adjusted odds ratio for having previously diagnosed DED was 1.677 (95% CI 1.299-2.166) for metropolitan cities and 1.580 (95% CI 1.215-2.055) for other cities compared to rural areas. Corresponding odds ratio for presenting DED symptoms was 1.388 (95% CI 1.090-1.766) for metropolitan cities and 1.271 (95% CI 0.999-1.617) for other cities. Lower humidity and longer sunshine duration were significantly associated with DED. Among air pollutants, SO₂ was associated with DED, while NO₂, O₃, CO, and PM10 were not.

Conclusion

Our findings suggest that prevalence of DED can be affected by the degree of urbanization and environmental factors such as humidity and sunshine duration.

【 授权许可】

   
2014 Um et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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