Analysis of the Wnt gene repertoire in an onychophoran provides new insights into the evolution of segmentation

EvoDevo

Ralf Janssen²  Nico Posnien¹  Alistair P McGregor³  Graham E Budd²  Anna Schönauer³  Mattias Hogvall² 

[1] Department of Developmental Biology, Georg-August-University Göttingen, Justus-von-Liebig-Weg 11, Göttingen, 37077, Germany;Department of Earth Sciences, Palaeobiology, Uppsala University, Villavägen 16, Uppsala, 75236, Sweden;Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, OX3 0BP, UK

关键词: Wnt signalling;    Segment polarity;    Segmentation;    Evolution;    Development;   

Others  :  801725
DOI  :  10.1186/2041-9139-5-14

 received in 2014-01-16, accepted in 2014-03-11,  发布年份 2014

【 摘 要 】

Background

The Onychophora are a probable sister group to Arthropoda, one of the most intensively studied animal phyla from a developmental perspective. Pioneering work on the fruit fly Drosophila melanogaster and subsequent investigation of other arthropods has revealed important roles for Wnt genes during many developmental processes in these animals.

Results

We screened the embryonic transcriptome of the onychophoran Euperipatoides kanangrensis and found that at least 11 Wnt genes are expressed during embryogenesis. These genes represent 11 of the 13 known subfamilies of Wnt genes.

Conclusions

Many onychophoran Wnt genes are expressed in segment polarity gene-like patterns, suggesting a general role for these ligands during segment regionalization, as has been described in arthropods. During early stages of development, Wnt2, Wnt4, and Wnt5 are expressed in broad multiple segment-wide domains that are reminiscent of arthropod gap and Hox gene expression patterns, which suggests an early instructive role for Wnt genes during E. kanangrensis segmentation.

【 授权许可】

   
2014 Hogvall et al.; licensee BioMed Central Ltd.

【 图 表 】

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