Is human cytomegalovirus associated with breast cancer progression?

Infectious Agents and Cancer

Martha-Eugenia Ruiz-Tachiquin¹  Alejandro Gómez-Delgado⁶  Penélope Aguilera²  Isabel Alvarado-Cabrero³  David Gómez-Rangel⁵  Hilda-Alicia Valdez-Salazar⁶  Dolores Utrera-Barillas⁴ 

[1] Medical Research Unit in Human Genetics, Pediatrics Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, 06720, Mexico;Cerebrovascular Pathology Laboratory, National Institute of Neurology and Neurosurgery, Mexico City, 14269, Mexico;Department of Pathology, Oncology Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, 06720, Mexico;Medical Research Unit in Oncological Diseases, Oncology Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, 06720, Mexico;Department of Medical Oncology, Oncology Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, 06720, Mexico;Medical Research Unit in Infectious Diseases, Pediatrics Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, 06720, Mexico

关键词: DNA;    Polymerase chain reaction;    Human cytomegalovirus;    Virus;    Progression;    Cancer;    Breast;   

Others  :  803126
DOI  :  10.1186/1750-9378-8-12

 received in 2012-12-13, accepted in 2013-03-22,  发布年份 2013

【 摘 要 】

Background

It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possible association with breast cancer progression. DNA from paraffin-embedded tissues was analyzed by real-time PCR. We investigated 20 fibroadenomas and 27 primary breast carcinomas (stages II, III, and IV).

Findings

Two carcinomas were positive for HCMV, one was positive for two TaqMan viral detection probes, and one was positive for a sole TaqMan viral detection probe (UL83), whereas the remainder of the samples was negative.

Conclusions

Samples studied showed no association between HCMV infection and breast cancer progression.

【 授权许可】

   
2013 Utrera-Barillas et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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