Management of locally advanced laryngeal cancer

Journal of Otolaryngology-Head & Neck Surgery

Heinrich Iro²  George A Velegrakis¹  Johannes Zenk²  Markus Kapsreiter²  Frank Waldfahrer²  Georgios Psychogios²  Alexander D Karatzanis¹ 

[1] Department of Otorhinolaryngology, Head and Neck Surgery, University of Crete Medical School, Heraklion, Crete, Greece;Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen-Nuremberg Medical School, Erlangen, Germany

关键词: Prognosis;    Treatment;    Local control;    Survival;    Advanced carcinoma;    Larynx;   

Others  :  861466
DOI  :  10.1186/1916-0216-43-4

 received in 2013-07-16, accepted in 2014-01-26,  发布年份 2014

【 摘 要 】

Background

Management of advanced laryngeal cancer is complex and ideal strategy is yet to be defined. This study evaluates the experience of a single head and neck oncologic centre in the management of T4 laryngeal cancer.

Methods

Retrospective assessment of cases primarily treated for T4a squamous cell carcinoma of the larynx, between 1980 and 2007, at a tertiary referral center.

Results

A total of 384 cases were studied. Five-year disease specific survival was 56.2% and local control 87.4%. Regional and distal control estimates were 90.3% and 88.3% respectively. Prognosis was significantly superior for cases treated with primary surgery compared to cases solely managed with non-surgical modalities. Positive surgical margins and regional disease worsened prognosis.

Conclusion

This study suggests that primary surgery remains a key element in the treatment of advanced laryngeal cancer. The need for well-designed, prospective, randomised studies in order to further evaluate the remaining role of primary surgery in the modern management of locally advanced laryngeal lesions is emphasized.

【 授权许可】

   
2014 Karatzanis et al.; licensee BioMed Central Ltd.

【 图 表 】

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