A microsurgical bifurcation rabbit model to investigate the effect of high-intensity focused ultrasound on aneurysms: a technical note

Journal of Therapeutic Ultrasound

Beat Werner²  Ernst Martin²  Jenny Kienzler¹  Salome Erhardt¹  Serge Marbacher¹  Javier Fandino¹  Daniel Coluccia¹ 

[1] Cerebrovascular Research Laboratory, Department of Intensive Care Medicine, University of Bern and Bern University Hospital, Bern, Switzerland;Center for MR Research, University Children’s Hospital, Zürich, Switzerland

关键词: Rabbit model;    Aneurysm;    Sonication;    Focused ultrasound;   

Others  :  1132941
DOI  :  10.1186/2050-5736-2-21

 received in 2014-05-18, accepted in 2014-09-23,  发布年份 2014

【 摘 要 】

Background

Recent clinical studies confirmed the high potential of MR-guided focused ultrasound (MRgFUS) in the field of functional neurosurgery. While its ability for precise thermo-ablation within soft tissue is widely recognized, the impact of high-intensity focused ultrasound (HIFU) on larger vessels is less explored. We used a bifurcation aneurysm model in rabbits to investigate the possible effects on the walls of vascular aneurysms and to assess the risk and prospect of this procedure for managing neurovascular disorders.

Methods

Experimental bifurcation aneurysms were microsurgically created in New Zealand white rabbits and sonicated using MRgFUS.

Results

A temperature of max. 54°C could be achieved close to the aneurysm, and the shape and size of the aneurysm were noticeably changed, as shown by MR angiography.

Conclusions

The presented rabbit model proved suitable and capable of being extended to acquire data on the effect of HIFU on aneurysms and larger vessels. The fact that HIFU led to an alteration of the aneurysm without inducing rupture encourages further investigations.

【 授权许可】

   
2014 Coluccia et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Figure 5.

【 参考文献 】

• [1]Fry WJ, Mosberg WH Jr, Barnard JW, Fry FJ: Production of focal destructive lesions in the central nervous system with ultrasound. J Neurosurg 1954, 11(5):471-8.
• [2]Elias WJ, Huss D, Voss T, Loomba J, Khaled M, Zadicario E, Frysinger RC, Sperling SA, Wylie S, Monteith SJ, Druzgal J, Shah BB, Harrison M, Wintermark M: A pilot study of focused ultrasound thalamotomy for essential tremor. N Eng J Med 2013, 369(7):640-8.
• [3]Martin E, Jeanmonod D, Morel A, Zadicario E, Werner B: High-intensity focused ultrasound for noninvasive functional neurosurgery. Ann Neurol 2009, 66(6):858-61.
• [4]Hynynen K, Colucci V, Chung A, Jolesz F: Noninvasive arterial occlusion using MRI-guided focused ultrasound. Ultrasound Med Biol 1996, 22(8):1071-7.
• [5]Vaezy S, Martin R, Kaczkowski P, Keilman G, Goldman B, Yaziji H, Carter S, Caps M, Crum L: Use of high-intensity focused ultrasound to control bleeding. J Vasc Surg 1999, 29(3):533-42.
• [6]Sherif C, Fandino J, Erhardt S, di Ieva A, Killer M, Kleinpeter G, Marbacher S: Microsurgical venous pouch arterial-bifurcation aneurysms in the rabbit model: technical aspects. J Vis Exp 2011., 51doi: 10.3791/2718
• [7]Monteith S, Sheehan J, Medel R, Wintermark M, Eames M, Snell J, Kassell NF, Elias WJ: Potential intracranial applications of magnetic resonance-guided focused ultrasound surgery. J Neurosurg 2013, 118(2):215-21.
• [8]McDannold NJ, Vykhodtseva NI, Hynynen K: Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology 2006, 241(1):95-106.