Effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes: a systematic review of interventional studies

Journal of Diabetes & Metabolic Disorders

Madhukar Mittal³  Jisha John⁴  Ammepa Anton¹  Nisha Nigil Haroon² 

[1] Toronto Western Hospital, University Health Network, Toronto, ON, Canada;Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, ON, Canada;Endocrinology Unit, Department of Medicine, King George Medical University, Lucknow, India;Department of Medicine, Wayne State University, Detroit, MI, USA

关键词: Type 2 diabetes;    Insulin sensitivity;    Glycemic control;    Vitamin D;    Cholecalciferol;   

Others  :  1133297
DOI  :  10.1186/s40200-015-0130-9

 received in 2014-09-17, accepted in 2015-01-25,  发布年份 2015

【 摘 要 】

Background

Diabetes and vitamin D deficiency are global epidemics. Researchers have long been exploring the role of potentially modifiable factors to manage type 2 diabetes. We conducted a systematic review of prospective studies and randomized controlled trials that involved vitamin D supplementation and specifically intended to study glycemic outcomes related to type 2 diabetes.

Methods

Two authors independently searched Medline and PubMed for longitudinal studies that had assessed the effect of vitamin D supplements on glycemic control, insulin resistance and beta-cell dysfunction in patients with diabetes.

Results

Seventeen randomized control trials and seven longitudinal studies with a minimum follow-up of one month were included.

Results of the various short-term studies (follow up ≤ 3 months) suggested that vitamin D supplementation had a positive impact on glycemic control and metabolic parameters such as insulin resistance and beta cell dysfunction. However, the evidence was weak due to the low methodological quality of the studies. There was no significant effect on HbA1c, beta cell function and insulin resistance in the long-term studies (follow up > 3 months). There existed heterogeneity in the methodology of the studies, inclusion criteria, mode of supplementation of vitamin D and the duration of follow up.

Conclusions

Current evidence based on randomized controlled trials and longitudinal studies do not support the notion that vitamin D supplementation can improve hyperglycemia, beta cell secretion or insulin sensitivity in patients with type 2 diabetes. Large-scale trials with proper study design, optimal vitamin D supplementation and longer follow up need to be conducted.

【 授权许可】

   
2015 Nigil Haroon et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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