Tumor immunology and cancer immunotherapy: summary of the 2013 SITC primer

Journal for ImmunoTherapy of Cancer

Padmanee Sharma³  Charles G Drake¹  Amanda J Walker²  Andrew B Sharabi²  Raju R Raval² 

[1] The Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

关键词: LAG-3;    PD-L1;    Bladder cancer;    Kidney cancer;    Prostate cancer;    Melanoma;    PD-1;    CTLA-4;   

Others  :  803414
DOI  :  10.1186/2051-1426-2-14

 received in 2014-03-26, accepted in 2014-04-10,  发布年份 2014

【 摘 要 】

Knowledge of the basic mechanisms of the immune system as it relates to cancer has been increasing rapidly. These developments have accelerated the translation of these advancements into medical breakthroughs for many cancer patients. The immune system is designed to discriminate between self and non-self, and through genetic recombination there is virtually no limit to the number of antigens it can recognize. Thus, mutational events, translocations, and other genetic abnormalities within cancer cells may be distinguished as “altered-self” and these differences may play an important role in preventing the development or progression of cancer. However, tumors may utilize a variety of mechanisms to evade the immune system as well. Cancer biologists are aiming to both better understand the relationship between tumors and the normal immune system, and to look for ways to alter the playing field for cancer immunotherapy. Summarized in this review are discussions from the 2013 SITC Primer, which focused on reviewing current knowledge and future directions of research related to tumor immunology and cancer immunotherapy, including sessions on innate immunity, adaptive immunity, therapeutic approaches (dendritic cells, adoptive T cell therapy, anti-tumor antibodies, cancer vaccines, and immune checkpoint blockade), challenges to driving an anti-tumor immune response, monitoring immune responses, and the future of immunotherapy clinical trial design.

【 授权许可】

   
2014 Raval et al.; licensee BioMed Central Ltd.

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