The role of BCL11B in hematological malignancy

Experimental Hematology & Oncology

Yangqiu Li¹  Xin Du²  Xin Huang² 

[1] Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, China;Department of Hematology, Guangdong General Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China

关键词: Targeted therapy;    Apoptosis;    Hematological malignancy;    Altered expression;    BCL11B;   

Others  :  814694
DOI  :  10.1186/2162-3619-1-22

 received in 2012-07-15, accepted in 2012-08-08,  发布年份 2012

【 摘 要 】

The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and cell proliferation. This review summarizes current data and knowledge concerning the alteration of BCL11B in hematological malignancies and its role as a potential target for therapies directed against T cell malignancies.

【 授权许可】

   
2012 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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