Rhinocerebral zygomycosis with pansinusitis in a 14-year-old girl with type 1 diabetes: a case report and review of the literature

Italian Journal of Pediatrics

Marzia Duse¹  Taulant Melengu¹  Ilaria Ernesti¹  Laura Schiavi¹  Claudio Di Biasi²  Vincenzo Savastano¹  Luigi Tarani¹  Francesco Costantino¹  Annalisa di Coste¹ 

[1] Department of Pediatrics, Policlinico Umberto I, “Sapienza” University of Rome, Viale Regina Elena 324, Rome 00161, Italy;Department of Radiology, Policlinico Umberto I, “Sapienza” University of Rome Viale Regina Elena 324, Rome 00161, Italy

关键词: Posaconazole;    Endoscopic Sinus Surgery;    Maxillary sinus;    Diabetes;    Rhinocerebral zygomycosis;   

Others  :  812352
DOI  :  10.1186/1824-7288-39-77

 received in 2013-10-10, accepted in 2013-12-07,  发布年份 2013

【 摘 要 】

Background

Zygomycosis is a rare life-threatening fungal infection affecting mostly patients with predisposing conditions such as diabetes mellitus, immunodeficiency, haemochromatosis or major trauma.

Methods

We describe a case of rhinocerebral zygomycosis in a girl with type 1 diabetes and review previous published cases and treatment options.

Results

A 14-year-old girl with type 1 diabetes mellitus occurred with dental pain, facial swelling, ecchymosis and left eye decreased visual acuity, unresponsive to antibiotic therapy. The coltures of the sinusal mucosa were positive for fungal species belonging to the Zygomycetes. She performed antifungal therapy with posaconazole (POS) with a very slow improvement and a poor glycemic control, leading to blindness of the left eye.

Conclusion

Our report adds further awareness on rhinocerebral zygomycosis and emphasizes on urgent diagnosis and timely management of this potentially fatal fungal infection through an adequate treatment.

【 授权许可】

   
2013 di Coste et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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