A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women

Journal of Translational Medicine

Maznah Ismail¹  Latiffah Ab Latiff²  Siti Aisyah Abd Ghafar¹  Saiful Nizam Abd Rashid⁴  Suraini Mohd Saini⁴  Mustapha Umar Imam¹  Rozi Mahmud⁴  Nurul Syima Hamdan³  Ramlah Mohamad Ibrahim³ 

[1] Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia;Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia;Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia;Department of Imaging, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia

关键词: Plant bioresources;    Nigella sativa;    Menopause;    Hyperlipidemia;    Complementary medicine;    Clinical trial;   

Others  :  817367
DOI  :  10.1186/1479-5876-12-82

 received in 2013-11-26, accepted in 2014-03-04,  发布年份 2014

【 摘 要 】

Background

The risk of cardiovascular diseases (CVD) is increased tremendously among menopausal women, and there is an increasing demand for alternative therapies for managing factors like dyslipidemia that contribute to CVD development.

Methods

In this study, Nigella sativa was evaluated for its hypolipidemic effects among menopausal women. In a randomised trial, hyperlipidemic menopausal women were assigned to treatment (n = 19) or placebo groups (n = 18), and given N. sativa or placebo for two months after their informed consents were sought. At baseline, blood samples were taken and at one month intervals thereafter until one month after the end of the study.

Results

The results showed that N. sativa significantly improved lipid profiles of menopausal women (decreased total cholesterol, low density lipoprotein cholesterol and triglyceride, and increased high density lipoprotein cholesterol) more than the placebo treatment over 2 months of intervention. One month after cessation of treatment, the lipid profiles in the N. sativa-treated group tended to change towards the pretreatment levels.

Conclusions

N. sativa is thought to have multiple mechanisms of action and is cost-effective. Therefore, it could be used by menopausal women to remedy hypercholesterolemia, with likely more benefits than with single pharmacological agents that may cause side effects. The use of N. sativa as an alternative therapy for hypercholesterolemia could have profound impact on the management of CVD among menopausal women especially in countries where it is readily available.

【 授权许可】

   
2014 Ibrahim et al.; licensee BioMed Central Ltd.

【 图 表 】

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