A synergistic approach towards understanding the functional significance of dopamine receptor interactions

Journal of Molecular Signaling

Harbinder S Dhillon¹  Mahlet D Mersha¹  Pratima Pandey² 

[1] Department of Biological Sciences, Center for Neuroscience Research, Delaware State University, Dover, DE 19901, USA;Department of Biological Sciences, Delaware State University, Mohali 140308, India

关键词: Caenorhabditis elegans;    Gα;    GPCR;    G-protein;    Dopamine receptor;   

Others  :  802359
DOI  :  10.1186/1750-2187-8-13

 received in 2012-10-08, accepted in 2013-11-18,  发布年份 2013

【 摘 要 】

The importance of the neurotransmitter dopamine (DA) in the nervous system is underscored by its role in a wide variety of physiological and neural functions in both vertebrates and invertebrates. Binding of dopamine to its membrane receptors initiates precise signaling cascades that result in specific cellular responses. Dopamine receptors belong to a super-family of G-protein coupled receptors (GPCRs) that are characterized by seven trans-membrane domains. In mammals, five dopamine receptors have been identified which are grouped into two different categories D1- and D2-like receptors. The interactions of DA receptors with other proteins including specific Gα subunits are critical in deciding the fate of downstream molecular events carried out by effector proteins. In this mini-review we provide a synopsis of known protein-protein interactions of DA receptors and a perspective on the potential synergistic utility of Caenorhabditis elegans as a model eukaryote with a comparatively simpler nervous system to gain insight on the neuronal and behavioral consequences of the receptor interactions.

【 授权许可】

   
2013 Pandey et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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