Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

Journal of Translational Medicine

Yihua An¹  Jianhua Gao²  Xiaodong Wang¹  Guanghui Dai¹  Rongrong Hua¹  Xuebin Liu¹  Hongbin Cheng¹ 

[1] Department of Cell Transplantation, General Hospital of Chinese people¿s Armed Police Forces, Beijing 100039, China;Department of CT Room Radiology, General Hospital of Chinese people¿s Armed Police Forces, Beijing 100039, China

关键词: Urodynamic examination;    Transplantation;    Spinal cord injury;    Umbilical cord mesenchymal stem cell;   

Others  :  1148085
DOI  :  10.1186/s12967-014-0253-7

 received in 2014-06-05, accepted in 2014-09-02,  发布年份 2014

【 摘 要 】

Background

Umbilical cord mesenchymal stem cells (UCMSCs) have a considerable advantage and potential in treating for central nervous system diseases and have become a novel alternative treatment for spinal cord injury. This study aims to compare the neurological function outcome of stem cell transplantation, rehabilitation therapy, and self-healing for sequelae of spinal cord injury.

Methods

Thirty-four cases of thoracolumbar spinal cord injury were randomly divided into three groups: the stem cell transplantation group was given CT-guided UCMSC transplantation twice; the rehabilitation group received rehabilitation therapy; and the blank control group did not receive any specific treatment. AIS grading, ASIA scoring, the manual muscle strength and muscle tension scale, and the Barthel index were used to evaluate the clinical outcome. Urodynamic examination was also performed for patients in the UCMSC group and the rehabilitation therapy group.

Results

Seven of the ten patients in the UCMSC group had significant and stable improvement in movement, self-care ability, and muscular tension; five of the forteen patients (36%) in the rehabilitation group also had certain improvement in these aspects. Urodynamic examination demonstrated that patients in the UCMSC group exhibited an increase in maximum urinary flow rate and maximum bladder capacity, as well as a decrease in residue urine volume and maximum detrusor pressure. The rehabilitation group exhibited decreased maximum bladder capacity, but no perceptible change in maximum urinary flow rate, residue urine volume or maximum detrusor pressure.

Conclusions

UCMSC transplantation can effectively improve neurological functional recovery after spinal cord injury, and its efficacy is superior to that of rehabilitation therapy and self-healing.

Trial registration

The present clinical study was registered at chictr.org (registration number: NCT01393977 webcite).

【 授权许可】

   
2014 Cheng et al.; licensee BioMed Central Ltd.

【 图 表 】

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