Medullary colon cancer presenting with total necrosis of all regional lymph node metastases: morphologic description of a presumed immune-mediated event

Diagnostic Pathology

Yves Bendavid¹  Andrew Mitchell² 

[1] Department of Surgery, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada;Department of Anatomic Pathology and Cytology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L¿Assomption, Montreal H1T 2M4, Quebec, Canada

关键词: Metastases;    Lymph node;    Necrosis;    Cancer;    Colon;    Medullary;   

Others  :  1149432
DOI  :  10.1186/s13000-014-0204-x

 received in 2014-07-16, accepted in 2014-10-08,  发布年份 2014

【 摘 要 】

Medullary carcinoma is a rare type of colon cancer with characteristic clinical and molecular features. Notably, despite its high-grade histology, the prognosis is generally better than for colonic adenocarcinoma of the usual type. We present herein a singular case of medullary colon cancer in which all of numerous lymph node metastases in the surgical resection specimen were completely necrotic in the face of a wholly viable primary tumor. Possible mechanisms are discussed with emphasis on immune-mediated factors.

Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_204 webcite

【 授权许可】

   
2014 Mitchell and Bendavid; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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