Plasma concentrations of D-dimer and outcome of in vitro fertilization

Journal of Ovarian Research

Gian Mario Tiboni¹  Valeria Di Donato¹  Ettore Porreca¹  Marcello Di Nisio² 

[1] Department of Medicine and Aging, University “G. D’Annunzio” of Chieti-Pescara, Chieti, Italy;Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands

关键词: Hypercoagulability;    D-dimer;    Clinical pregnancy;    In-vitro fertilization;   

Others  :  801181
DOI  :  10.1186/1757-2215-7-58

 received in 2014-02-14, accepted in 2014-05-09,  发布年份 2014

【 摘 要 】

Background

The activation of blood coagulation could contribute to the failure of in-vitro fertilization (IVF) techniques. The aim of this study was to assess the predictive value of D-dimer levels for pregnancy outcome in women undergoing IVF.

Findings

A prospective study was performed in 105 women undergoing IVF. D-dimer was measured before and one week after the administration of recombinant human chorionic gonadotropin (r-hCG). The primary outcome of the study was clinical pregnancy. The mean age was 36 years (range 26 to 43 years). The main indications for IVF were infertility due to a tubaric (n = 21, 20%) or male factor (n = 37, 35%) and idiopathic infertility (n = 30, 29%) which altogether accounted for 84% of the total. Clinical pregnancy was achieved by 40/105 (38%) women of whom 32 (80%) delivered a live child. On the day of r-hCG administration, D-dimer concentrations were significantly higher in patients not achieving a clinical pregnancy (141 ng/dL vs. 115 ng/dL, p = 0.035) which remained statistically significant after correction for age and indications for IVF in multivariable analysis (p = 0.032). One week after r-hCG, the levels of D-dimer were significantly increased both in women with and without a clinical pregnancy with no differences between the groups (748 ng/dL vs. 767 ng/dL, p = 0.88).

Conclusions

D-dimer concentrations seem to predict a higher risk of pregnancy failure in women undergoing IVF. If confirmed in future prospective studies, D-dimer could help identifying a group of patients who could benefit from prophylaxis to increase the pregnancy success rate.

【 授权许可】

   
2014 Di Nisio et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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