Analysis of endometrial thickness patterns and pregnancy outcomes considering 12,991 fresh IVF cycles

BMC Medical Informatics and Decision Making

ShuJie Liao¹  Renjie Wang¹  Lei Jin¹  Wei Pan²  Wulin Pan³  Cheng Hu³  Dongyang Yu³ 

[1] Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, People’s Republic of China;School of Applied Economics, Renmin University of China, 100872, Beijing, People’s Republic of China;School of Economic and Management, Wuhan University, 430072, Wuhan, People’s Republic of China;

关键词: In vitro fertilization;    Endometrial thickness;    Endometrial pattern;    Clinical pregnancy;   

DOI  :  10.1186/s12911-021-01538-2

来源: Springer

【 摘 要 】

BackgroundDifferent endometrial patterns have an important effect on the relationship between endometrial thickness (EMT) and clinical pregnancy rate. There is a significant difference in age, selection of cycle protocols, and clinical pregnancy rates among four groups with diverse endometrial patterns.MethodsThis retrospective study aimed to assess the association between EMT on human chorionic gonadotropin (HCG) administration day and the clinical outcome of fresh in vitro fertilization (IVF). The 5th, 50th, and 95th percentiles for EMT were determined as 8, 11, and 14 mm, respectively. Patients were sub-divided into four groups based on their EMT in different endometrial patterns (Group 1: < 8 mm; Group 2: ≥ 8 and ≤ 11 mm; Group 3: > 11 and ≤ 14 mm; Group 4: > 14 mm). We divided patients into three groups based on their endometrial pattern and evaluated the correlation between EMT and clinical pregnancy rate.ResultsWe found a positive correlation between pregnancy rates and EMT in all endometrial patterns. Multiple logistic regression analysis proved age, duration of infertility, cycle protocols, number of embryos transferred, progesterone on HCG day, endometrial patterns, and EMT have significant effects on clinical pregnancy rates. Meanwhile, there was a significant difference in age, selection of cycle protocols, and clinical pregnancy rates among four groups with diverse endometrial patterns.ConclusionsDifferent endometrial patterns have an important effect on the relationship between EMT and clinical pregnancy rate.

【 授权许可】

CC BY