Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors

Journal of Biological Engineering

Majid Bazargan¹  Seyed Mojtaba Mousavi Nayinian¹  Hossein Bazmara¹  Kaamran Raahemifar²  M Soltani³  Mostafa Sefidgar¹ 

[1] Department of Mechanical Engineering, K. N. T. University of Technology, Tehran, Iran;Electrical & Computer Department of Ryerson University, Toronto, Ontario;Division of Nuclear Medicine, Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD, USA

关键词: Tissue transport properties;    Tumor shape and size;    Solid tumor;    Drug concentration;   

Others  :  804571
DOI  :  10.1186/1754-1611-8-12

 received in 2014-02-24, accepted in 2014-05-30,  发布年份 2014

【 摘 要 】

Background

The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on drug delivery to solid tumor.

Methods

The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and drug delivery are investigated.

Results

Sensitivity analysis shows that drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases drug concentration in interstitial fluid. This study shows that dependency of drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible.

Conclusions

This study shows that among diffusion and convection mechanisms of drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the drug concentration is larger than that of other tumors at the same time post injection.

【 授权许可】

   
2014 Sefidgar et al.; licensee BioMed Central Ltd.

【 图 表 】

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