Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma

Diagnostic Pathology

Mariângela Esther Alencar Marques²  Hamilton Ometto Stolf¹  Eloísa Bueno Pires de Campos¹  Vinicius Souza¹  Tania Munhoz¹  José Cândido Caldeira Xavier-Júnior² 

[1] UNESP- Universidade Estadual Paulista Radiology and Dermatology Department, Botucatu, SP, Brazil;Department of Pathology, Botucatu Medical School, Paulista State University (UNESP), Rubião Júnior s/n 18618-970, Botucatu, SP, Brazil

关键词: Acral Lentiginous Melanoma;    Cancer;    Dermatopathology;    Melanoma;   

Others  :  1219374
DOI  :  10.1186/s13000-015-0307-z

 received in 2014-11-03, accepted in 2015-05-29,  发布年份 2015

【 摘 要 】

Background

Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.

Case report

A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.

Conclusion

Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1513617994148349.

【 授权许可】

   
2015 Xavier-Júnior et al.

【 图 表 】

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